4.7 Article

Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/ Akt/Nrf2 signaling pathway

期刊

INTERNATIONAL IMMUNOPHARMACOLOGY
卷 113, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.intimp.2022.109398

关键词

Fibroblast growth factor 10; Particulate matter; Lung injury; Pyroptosis; Oxidative stress

资金

  1. National Nature Science Foundation of China
  2. Zhejiang Provincial Science Technology Department Foundation
  3. Wenzhou Technology Foundation
  4. [82170017]
  5. [2022RC203]
  6. [Y20220035]

向作者/读者索取更多资源

FGF10 protects against PM-induced lung injury by activating the PI3K/Akt/Nrf2 pathway, thereby alleviating oxidative damage and pyroptosis.
Particulate matter (PM) is a major environmental contaminant that causes and worsens respiratory diseases. Fibroblast growth factor 10 (FGF10), a paracrine fibroblast growth factor that specifically stimulates repair and regeneration after injury, has been shown to protect against PM-induced lung injury. However, the underlying mechanisms are still unclear. In this study, the protective effects of FGF10 were investigated using a PM-induced lung injury mouse model in vivo and BEAS-2B cells in vitro. According to the findings, FGF10 treatment alleviated PM-induced oxidative damage and pyroptosis in vivo and in vitro. Mechanistically, FGF10 activated antioxidative Nrf2 signaling. Inhibition of PI3K signaling with LY294002 or Nrf2 signaling with ML385 revealed that FGF10mediated lung protection was mediated by the PI3K/Akt/Nrf2 pathway. These results collectively indicate that FGF10 inhibits oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 pathway, suggesting a possible therapy for PM-induced lung injury.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据