Mitoquinone alleviates bleomycin-induced acute lung injury via inhibiting mitochondrial ROS-dependent pulmonary epithelial ferroptosis

Article Cell Biology

The role of ferroptosis in acute lung injury

Xin Liu et al.

Summary: This review summarizes the recent discoveries on the role of ferroptosis in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) to provide new strategies for its prevention and treatment.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

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Article Environmental Sciences

Arsenic induces ferroptosis and acute lung injury through mtROS-mediated mitochondria-associated endoplasmic reticulum membrane dysfunction

Meng-Die Li et al.

Summary: This study found that dysfunction of mitochondria-associated endoplasmic reticulum membrane (MAMs) is involved in arsenic-induced pulmonary ferroptosis and acute lung injury (ALI).

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Immunology

Mitochondria-derived reactive oxygen species are involved in renal cell ferroptosis during lipopolysaccharide-induced acute kidney injury

Nan-Nan Liang et al.

Summary: This study found that mitochondria-derived reactive oxygen species (ROS) contribute to renal cell ferroptosis during lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Inhibition of ferroptosis and scavenging of mitochondrial ROS with specific inhibitors, ferrostatin-1 and MitoQ, respectively, attenuated renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage, and renal cell death. These findings suggest that mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Critical Care Medicine

Cell-Cell Interaction Mechanisms in Acute Lung Injury

Huiting Zhou et al.

Summary: ALI and ARDS are caused by an exaggerated inflammatory response from various pulmonary and systemic insults. Lung tissue consists of different cell populations that work together to regulate lung inflammation, but the communication between different types of pulmonary cells in modulating inflammatory cascades is not fully understood.

SHOCK (2021)

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Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Immunology

Vasoactive intestinal peptide attenuates bleomycin-induced murine pulmonary fibrosis by inhibiting epithelial-mesenchymal transition: Restoring autophagy in alveolar epithelial cells

Jia-Xi Duan et al.

Summary: The study demonstrates that VIP attenuates bleomycin-induced pulmonary fibrosis in mice through restoring autophagy in alveolar epithelial cells, with anti-epithelial-mesenchymal transition (EMT) effects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Toxicology

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis

Rajasekaran Subbiah et al.

Summary: This review summarizes the latest publications related to paraquat-induced lung toxicity and the underlying molecular mechanisms. Paraquat poisoning mainly causes acute lung injury/acute respiratory distress syndrome, followed by pulmonary fibrosis.

CRITICAL REVIEWS IN TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/ Drp1 pathway

Lei Hou et al.

Summary: The study demonstrates that MitoQ can alleviate LPS-induced AEC damage by preventing Nrf2/Drp1-mediated mitochondrial fission, AEC apoptosis, and barrier breakdown, exerting a protective effect in ALI.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Biochemistry & Molecular Biology

MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism

Mengyuan Cen et al.

Summary: The study indicates that excessive ROS production and mitochondrial dysfunction during ALI and ARDS aggravate inflammation, and the mitochondria-targeted antioxidant mitoQ plays a crucial role in mitigating these effects, maintaining mitochondrial homeostasis, inhibiting endothelial cell apoptosis, alleviating endothelial disruption, and regulating lung inflammation through the Nrf2-MafF/ARE pathway.

REDOX BIOLOGY (2021)

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Review Cell Biology

Macrophages in Lung Injury, Repair, and Fibrosis

Peiyong Cheng et al.

Summary: Fibrosis progression in the lung can lead to impaired gas exchange, respiratory failure, or even death. Macrophages play a crucial role in response to lung injury, repair, and fibrosis, with their activation and polarization being key factors in the process. Targeting macrophages may offer potential benefits in alleviating pulmonary fibrosis.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Generation of Reactive Oxygen Species by Mitochondria

Pablo Hernansanz-Agustin et al.

Summary: The paper comprehensively reviews the production of ROS at a mitochondrial level, discusses recent advances in signaling and disease, and the role of supercomplexes in these mechanisms.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis

Yue Zhang et al.

Summary: Cigarette smoke induces senescence of AT2 cells via a SIRT1/autophagy dependent pathway, involving mitochondrial reactive oxygen species and DNA damage. Activating SIRT1 can reduce senescence by promoting autophagy.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Respiratory System

Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis

Bin Tong et al.

Summary: The study demonstrated that TUDCA could alleviate BLM-induced lung damage, inflammation, interstitial collagen deposition, and pulmonary Smad2/3 phosphorylation, while also inhibiting the reduction of vascular smooth muscle actin and E-cadherin. Additionally, TUDCA can suppress cell proliferation and oxidative stress in the lungs, suggesting a potential therapeutic effect in preventing lung fibrosis.

BMC PULMONARY MEDICINE (2021)

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Article Environmental Sciences

Reactive oxygen species-evoked endoplasmic reticulum stress mediates 1-nitropyrene-induced epithelial-mesenchymal transition and pulmonary fibrosis

Lin Fu et al.

Summary: Chronic exposure to 1-nitropyrene (1-NP) induces pulmonary fibrosis in mice, potentially through oxidative stress-induced endoplasmic reticulum stress leading to epithelial-mesenchymal transition.

ENVIRONMENTAL POLLUTION (2021)

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Article Medicine, Research & Experimental

Sevoflurane inhibits ferroptosis: A new mechanism to explain its protective role against lipopolysaccharide-induced acute lung injury

Xiao Liu et al.

Summary: Sevoflurane exerts a protective effect on lipopolysaccharide-induced acute lung injury by regulating ferroptosis through up-regulating HO-1 expression, which may provide a possible mechanism for its application in clinical anesthesia.

LIFE SCIENCES (2021)

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Review Cell Biology

Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat

Gloria E. Villalpando-Rodriguez et al.

Summary: Reactive oxygen species (ROS) are crucial for cellular signaling and stress response, with different levels and types affecting a cell's ability to undergo cell death and being associated with dysregulation of antioxidant pathways. Cell death can occur through various mechanisms, with ROS playing essential roles in different types of cell death and controlling the mechanisms involved.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Cell Biology

Mitochondria regulation in ferroptosis

Hai Wang et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch

Flavio R. Palma et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Biochemistry & Molecular Biology

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

Pengfei Liu et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2020)

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Article Biochemistry & Molecular Biology

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

Yingchuan Li et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Biochemistry & Molecular Biology

Toll interacting protein protects bronchial epithelial cells from bleomycin-induced apoptosis

Xiaoyun Li et al.

FASEB JOURNAL (2020)

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Article Immunology

Effect of curcumin on IL-17A mediated pulmonary AMPK kinase/cyclooxygenase-2 expressions via activation of NFκB in bleomycin-induced acute lung injury in vivo

Sadiya Bi Shaikh et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice

Ae Rin Baek et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Pharmacology & Pharmacy

Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury

Melissa L. Wilkinson et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

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Article Physiology

Role of phospholipase D in bleomycin-induced mitochondrial reactive oxygen species generation, mitochondrial DNA damage, and pulmonary fibrosis

Vidyani Suryadevara et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

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Review Cell Biology

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Lian-Jiu Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Review Toxicology

Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants

Debra L. Laskin et al.

TOXICOLOGICAL SCIENCES (2019)

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Article Respiratory System

Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-β/Smad2/3-mediated epithelial-mesenchymal transition

Se-Ruo Li et al.

RESPIRATORY RESEARCH (2019)

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Review Pediatrics

Acute Lung Toxicity After Intralesional Bleomycin Sclerotherapy

Ana Mendez-Echevarria et al.

PEDIATRICS (2018)

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Article Respiratory System

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension

Oleg Pak et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

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Article Biochemistry & Molecular Biology

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

Anja Jelinek et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Alveolar Micromechanics in Bleomycin-induced Lung Injury

Lars Knudsen et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Article Toxicology

Calcitriol inhibits bleomycin-induced early pulmonary inflammatory response and epithelial-mesenchymal transition in mice

Zhu-Xia Tan et al.

TOXICOLOGY LETTERS (2016)

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Article Cell Biology

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

Sandra Cabrera et al.

AUTOPHAGY (2015)

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Article Physiology

Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner

Hironobu Tsubouchi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)

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Review Biochemistry & Molecular Biology

The role of iron and reactive oxygen species in cell death

Scott J. Dixon et al.

NATURE CHEMICAL BIOLOGY (2014)

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Article Food Science & Technology

Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity in Wistar rats

Saba et al.

FOOD AND CHEMICAL TOXICOLOGY (2013)

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Article Medicine, Research & Experimental

Role of survivin in acute lung injury: epithelial cells of mice and humans

Yasuhiro Terasaki et al.

LABORATORY INVESTIGATION (2013)

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Article Respiratory System

Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice

S. Tajima et al.

EUROPEAN RESPIRATORY JOURNAL (2008)

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Mitoquinone alleviates bleomycin-induced acute lung injury via inhibiting mitochondrial ROS-dependent pulmonary epithelial ferroptosis

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