期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 113, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2022.109371
关键词
Gastric cancer; Peripheral lymphocyte count; NLR; Survival; Prognosis
资金
- Science Technology Project of Zhejiang Province
- Science and Technology Bureau of Taizhou
- [2020R52060]
- [20ywa03]
Pre-operative NLR is an independent prognostic factor for patients with gastric cancer and has stratified prognostic value for patients with AJCC stage III.
Objective: To evaluate the prognostic significance of peripheral lymphocyte count and its derived inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), in a cohort of patients with gastric cancer (GC).Methods: In this retrospective study, the clinical characteristics and follow-up information, both pre- and postoperative within one week of laboratory findings, of 338 patients with GC who underwent radical gastrectomy were retrieved, and their prognostic significance was evaluated.Results: Both lower pre- and post-operative lymphocyte counts and higher NLR and SSI were significantly related to advanced tumour (pT) and disease stages (American Joint Committee on Cancer [AJCC]) in patients with GC. Log-rank survival analysis showed that, in addition to traditional pT, pN, pM, and AJCC stages, both lower pre(p = 0.041) and post-operative (p = 0.002) lymphocyte counts and higher NLR (ppre < 0.001 and ppost = 0.008) and SSI (ppre = 0.014 and ppost = 0.145) were associated with worse survival. Cox proportional hazards analysis revealed that pre-operative NLR (p = 0.018; hazard ratio = 1.778) was an independent predictor of prognosis in patients with GC. Moreover, when the pre-operative NLR was divided into NLRlow and NLRhigh, NLRhigh showed stratified prognostic value for patient sex (male, p = 0.001; female, p = 0.044), age (younger, p = 0.005; older, p = 0.005), and AJCC stage III (p = 0.007). Conclusion: Pre-operative NLR is an independent prognostic factor for patients with GC and has stratified prognostic value for patients with AJCC stage III GC.
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