☆ 4.7 Article

Chemokine CCL5 immune subtypes of human liver cancer with prognostic significance

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Medicine, Research & Experimental

Hepatocellular Carcinoma Immunotherapy

Rubens Copia Sperandio et al.

Summary: Hepatocellular carcinoma (HCC) is a common primary liver malignancy and a leading cause of cancer-related death. Single-agent anti-PD-1 immune checkpoint inhibitors (ICIs) showed initial promise, but failed to demonstrate efficacy in phase III trials. The combination of atezolizumab and bevacizumab has been approved as first-line therapy, showing significant improvements in response rate, progression-free survival, and overall survival compared to standard treatments. Ongoing clinical trials are evaluating the use of ICIs in combination with other drugs.

ANNUAL REVIEW OF MEDICINE (2022)

添加到收藏夹

Review Oncology

The Liver-Immunity Nexus and Cancer Immunotherapy

James C. Lee et al.

Summary: Liver metastases have a significant impact on the effectiveness of immune checkpoint inhibitors in patients with solid-tumor malignancies. Multiple clinical and translational studies have shown that liver metastasis leads to systemic immune suppression through the generation of suppressive macrophages and activation of regulatory T-cells. Various interventions, such as radiation therapy and combination checkpoint blockade, have been reported to address liver immune suppression.

CLINICAL CANCER RESEARCH (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Intratumoral γδ T-Cell Infiltrates, Chemokine (C-C Motif) Ligand 4/Chemokine (C-C Motif) Ligand 5 Protein Expression and Survival in Patients With Hepatocellular Carcinoma

Na Zhao et al.

Summary: The study found an increased infiltration of gamma delta T cells in the tumor microenvironment of HCC patients, positively correlated with the expression of immune-related genes. Interaction between CCL4/CCL5 and their receptors CCR1/CCR5 may facilitate the recruitment of gamma delta T cells from peripheral blood or surrounding areas to tumor regions.

HEPATOLOGY (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver

Max Preti et al.

Summary: The study revealed that in autoimmune hepatitis (AIH), autoreactive T cells can attack the liver due to increased plasticity and instability of autoantigen-specific Tregs.

JCI INSIGHT (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Regulation and functional roles of chemokines in liver diseases

Sheng Cao et al.

Summary: This review summarizes the latest research on the function of chemokines in liver diseases, focusing on three main aspects: an overview of chemokine biology, the roles of chemokines in liver homeostasis, and therapeutic opportunities targeting chemokines in the treatment of liver diseases.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

添加到收藏夹

Article Immunology

Identification of Prognostic Genes in the Tumor Microenvironment of Hepatocellular Carcinoma

Shixin Xiang et al.

Summary: This study identified three key genes related to the TME and had prognostic significance in HCC, which may be promising markers for predicting immunotherapy outcomes. The higher immune/stromal/Estimate scores were significantly associated with better survival benefits in HCC, while the tumor purity showed a reverse trend. DEGs based on both immune and stromal scores primarily affected the cytokine-cytokine receptor interaction signaling pathway, with CASKIN1, EMR3, and GBP5 genes found most significantly associated with survival.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Oncology

Immunotherapy for Hepatocellular Carcinoma: Current Limits and Prospects

Cheng Zhong et al.

Summary: This review summarizes immune tolerance and immunotherapeutic strategies for hepatocellular carcinoma (HCC), as well as the main challenges of current therapeutic approaches, and presents alternative strategies for overcoming these limitations.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Medicine, General & Internal

The association between CD8+tumor-infiltrating lymphocytes and the clinical outcome of cancer immunotherapy: A systematic review and meta-analysis

Feng Li et al.

Summary: The study found that high CD8+ TILs were significantly associated with better overall survival, progression-free survival, and objective response rate in cancer patients treated with ICIs. High CD8+ TILs predicted treatment outcomes across different cancers and treatment types.

ECLINICALMEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types

Szu-Yuan Wu et al.

Summary: MXD3 plays a crucial role in cancer development and immune evasion, serving as a promising biomarker for cancer detection, prognosis, therapeutic design, and follow-up.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

添加到收藏夹

Article Cell Biology

CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma

Yurong Gu et al.

AGING-US (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Quantitative Proteomics of the Cancer Cell Line Encyclopedia

David P. Nusinow et al.

CELL (2020)

添加到收藏夹

Article Oncology

Biological and Clinical Significance of the CCR5/CCL5 Axis in Hepatocellular Carcinoma

Santosh K. Singh et al.

CANCERS (2020)

添加到收藏夹

Review Genetics & Heredity

mRNAs, proteins and the emerging principles of gene expression control

Christopher Buccitelli et al.

NATURE REVIEWS GENETICS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

TET2 promotes anti-tumor immunity by governing G-MDSCs andCD8+T-cell numbers

Shuangqi Li et al.

EMBO REPORTS (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Immunotherapy in hepatocellular carcinoma

Luigi Buonaguro et al.

ANNALS OF HEPATOLOGY (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

From NASH to HCC: current concepts and future challenges

Quentin M. Anstee et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

TOX is a critical regulator of tumour-specific T cell differentiation

Andrew C. Scott et al.

NATURE (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

Timothy M. Nywening et al.

GUT (2018)

添加到收藏夹

Review Immunology

Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach

Hadi Rezaeeyan et al.

APMIS (2018)

添加到收藏夹

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanisms of NAFLD development and therapeutic strategies

Scott L. Friedman et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells

Santosh Kumar Singh et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Oncology

Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

Xiaoguang Li et al.

GUT (2017)

添加到收藏夹

Article Oncology

Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model

Kun-Yu Teng et al.

MOLECULAR CANCER THERAPEUTICS (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

Daniela Sia et al.

GASTROENTEROLOGY (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Risk of Hepatocellular Cancer in HCV Patients Treated With Direct-Acting Antiviral Agents

Fasiha Kanwal et al.

GASTROENTEROLOGY (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Hepatitis C Virus-Induced CCL5 Secretion From Macrophages Activates Hepatic Stellate Cells

Reina Sasaki et al.

HEPATOLOGY (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Functional role of CCL5/RANTES for HCC progression during chronic liver disease

Antje Mohs et al.

JOURNAL OF HEPATOLOGY (2017)

添加到收藏夹

Article Oncology

Identification of chemokine CXCL10 in tumor microenvironment by antibody array as a prognostic marker in hepatocellular carcinoma

L. Li et al.

NEOPLASMA (2017)

添加到收藏夹

Review Immunology

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

Nisha Nagarsheth et al.

NATURE REVIEWS IMMUNOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Chunhong Zheng et al.

CELL (2017)

添加到收藏夹

Article Immunology

Tumour-activated liver stromal cells regulate myeloid-derived suppressor cells accumulation in the liver

H. Zhang et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

CXCL13 rather than IL-31 is a potential indicator in patients with hepatocellular carcinoma

Bing Li et al.

CYTOKINE (2017)

添加到收藏夹

Article Oncology

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

Tobias Eggert et al.

CANCER CELL (2016)

添加到收藏夹

Review Immunology

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

Vinit Kumar et al.

TRENDS IN IMMUNOLOGY (2016)

添加到收藏夹

Review Oncology

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

Suzanne L. Topalian et al.

NATURE REVIEWS CANCER (2016)

添加到收藏夹

Review Gastroenterology & Hepatology

Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways

Ekihiro Seki et al.

HEPATOLOGY (2015)

添加到收藏夹

Article Genetics & Heredity

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Kornelius Schulze et al.

NATURE GENETICS (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

Inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma

Ke-Qi Han et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

添加到收藏夹

Article Oncology

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages

Ji-Ye Kee et al.

BMC CANCER (2014)

添加到收藏夹

Review Gastroenterology & Hepatology

Roles for Chemokines in Liver Disease

Fabio Marra et al.

GASTROENTEROLOGY (2014)

添加到收藏夹

Article Cell Biology

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

Steven L. Highfill et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

添加到收藏夹

Article Oncology

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells

Maylis Dagouassat et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

添加到收藏夹

Review Gastroenterology & Hepatology

Chemokines and hepatocellular carcinoma

Fan Huang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.