Highly sensitive electrochemical detection of paracetamol based on MnO2/MWCNTs-NH2 composite

Herein, MnO2 nanosheets with good catalytic performance and MWCNTs-NH2 with good conductivity were combined to form MnO2/MWCNTs-NH2 composite with synergistic conductivity and catalytic performance. Subsequently, a novel PAR electrochemical sensor was constructed based on MnO2/MWCNTs-NH2 composite. Some important conditions such as enrichment time, pH value of PBS and modification volume of MnO2/ MWCNTs-NH2 were optimized to obtain the best detection performance for PAR. The synergistic catalytic effect of MWCNTs-NH2 and MnO2 endowed the composite with good catalytic performance toward the oxidation of PAR. The sensor presented a wide linear range from 0.001 to 20 mu M and a low detection limit of 1 nM. Addi-tionally, the sensor exhibited satisfactory reproducibility, repeatability, stability, selectivity, and was successfully applied for the detection of PAR in urine samples.

Automated summary

In this study, MnO2 nanosheets and MWCNTs-NH2 were combined to form a composite (MnO2/MWCNTs-NH2) with synergistic conductivity and catalytic performance. The composite was used to construct a novel PAR electrochemical sensor, which exhibited excellent detection performance and was successfully applied for PAR detection in urine samples.