Asprosin Exacerbates Endothelium Inflammation Induced by Hyperlipidemia Through Activating IKKβ-NF-κBp65 Pathway

Article Endocrinology & Metabolism

Oxidative Stress and Inflammation Are Associated With Age-Related Endothelial Dysfunction in Men With Low Testosterone

Matthew C. Babcock et al.

Summary: Low testosterone in middle-aged/older men is associated with age-associated endothelial dysfunction, potentially due to increased oxidative stress and inflammation.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Clinical Neurology

MicroRNA-155-5p Targets SKP2, Activates IKKβ, Increases Aβ Aggregation, and Aggravates a Mouse Alzheimer Disease Model

Wei Wang et al.

Summary: The study revealed that IKKβ and miR-155-5p play important roles in improving cognitive impairment and reducing Aβ deposition in APP/PS1 mice, while SKP2 has negative effects on exacerbating cognitive impairment and promoting Aβ deposition.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2022)

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Review Endocrinology & Metabolism

The dietary inflammatory index, obesity, type 2 diabetes, and cardiovascular risk factors and diseases

Rohit Hariharan et al.

Summary: Research suggests that an unhealthy diet is associated with an increased risk of obesity, T2DM, and CVD, but there is limited research on the association between dietary inflammation and T2DM and its risk factors, as well as a lack of interventional studies designed to change the inflammatory potential of diets and study its effect on cardiometabolic risk factors and diseases. Interventions studies are recommended to assess whether changes in DII can independently modulate cardiometabolic risk factors and diseases.

OBESITY REVIEWS (2022)

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Article Immunology

ML365 inhibits lipopolysaccharide-induced inflammatory responses via the NF-xB signaling pathway

Saisai Liu et al.

Summary: This study evaluated the anti-inflammatory effect of ML365 and revealed its mechanism of action. The results showed that ML365 inhibited NF-xB signaling pathway and suppressed LPS-induced inflammation.

IMMUNOBIOLOGY (2022)

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Review Geriatrics & Gerontology

Harnessing the Power of Leptin: The Biochemical Link Connecting Obesity, Diabetes, and Cognitive Decline

Patricia Grasso

Summary: This review examines the role of leptin in energy balance, glycemic regulation, and cognitive function, and explores its involvement in maintaining the homeostatic harmony of these physiologies. The effects of exercise on leptin levels and the results of clinical application of leptin to metabolic disease and neurologic dysfunction are summarized. Additionally, pre-clinical evidence suggests the potential use of synthetic peptide leptin mimetics in resolving leptin resistance, insulin resistance in type 2 diabetes, and insulin resistance associated with certain neurologic deficits.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Medicine, Research & Experimental

Inhibition of IKKβ/NF-κB signaling facilitates tendinopathy healing by rejuvenating inflamm-aging induced tendon-derived stem/progenitor cell senescence

Chongyang Wang et al.

Summary: Degenerative rotator cuff tendinopathy (RCT) is a common chronic tendon disease in the elderly population. Inflamm-aging leads to stem cell senescence, which in turn triggers RCT. Blocking the IKK beta/NF-kappa B pathway in vivo can reverse this process, providing a new approach for RCT treatment.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Biotechnology & Applied Microbiology

MicroRNA-486-5p functions as a diagnostic marker for carotid artery stenosis and prevents endothelial dysfunction through inhibiting inflammation and oxidative stress

Bin Zhu et al.

Summary: This study explores the expression changes of miR-486-5p in the serum of CAS patients and its mechanism. It found that miR-486-5p can serve as a biomarker for early identification of CAS and prevent endothelial dysfunction, possibly through anti-inflammatory and anti-oxidative effects targeting NFAT5.

BIOENGINEERED (2022)

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Article Biochemistry & Molecular Biology

IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells

Xueqiang Peng et al.

Summary: The study investigates the effects of constitutively active IKK beta subunits on the interaction between autophagy and endosomal systems in tumor cells. Results confirm that CA-IKK beta induces autophagosome accumulation, drives amphisome formation, and inhibits lysosomal-dependent degradation pathway. Additionally, CA-IKK beta promotes amphisome-plasma membrane fusion and small extracellular vesicle secretion.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Oncology

Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury

Noureddine Ben Khalaf et al.

Summary: In this study, it was shown that ERp72 is overexpressed on vascular endothelial cells in the early phase of the inflammatory response following skeletal muscle injury. This upregulation of ERp72 may potentially play a role in skeletal muscle inflammation and modulate leukocyte-endothelial cell interactions.

MOLECULAR MEDICINE REPORTS (2021)

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Article Biochemistry & Molecular Biology

Myeloid differentiation protein 2 mediates angiotensin II-induced inflammation and mesenchymal transition in vascular endothelium

Jinfu Qian et al.

Summary: Studies show that MD2 plays a crucial role in Ang II-induced vascular inflammation and EndMT, suggesting that MD2 could be targeted to mitigate inflammatory cardiovascular and EndMT-associated diseases.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Review Nutrition & Dietetics

Asprosin-A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature

Agnieszka Irena Mazur-Bialy

Summary: Asprosin is a recently discovered protein released during fasting conditions that plays a role in regulating the body's energy balance. Studies have shown that levels of asprosin are elevated in obesity and related diseases, but the administration of anti-asprosin antibodies can reduce food intake. Additionally, asprosin is associated with fertility and can improve fertility potential by enhancing sperm motility.

NUTRIENTS (2021)

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Article Neurosciences

Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells

Yun Lim et al.

Summary: The research suggests that palmitate can reduce hypothalamic cell stress induced by starvation by inhibiting ER-phagy, thus lowering the level of ER stress.

MOLECULAR BRAIN (2021)

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Review Biochemistry & Molecular Biology

Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence

Kiran Shabir et al.

Summary: White adipose tissue releases adipokines that regulate metabolic balance and physiological processes, with altered secretion profiles linked to obesity and cardio-metabolic diseases. Asprosin, a recently discovered adipokine, plays a key role in stimulating glucose secretion and appetite, and may have effects on various metabolic tissues.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

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Article Toxicology

USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-κB/ROS signaling

Zeyu Jiang et al.

Summary: The study demonstrated that USP18 may resist LPS-induced oxidative stress and inflammatory response in hPMVECs by inhibiting the TLR4/NF-κB/ROS signaling pathway, providing new and complementary strategies for ALI treatment.

TOXICOLOGY IN VITRO (2021)

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Review Endocrinology & Metabolism

Adipocyte-Endothelium Crosstalk in Obesity

Rugivan Sabaratnam et al.

Summary: Obesity disrupts the interaction between adipose tissue and endothelial cells, impacting systemic energy balance and metabolic health.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet

Liang Xu et al.

Summary: The study showed that supplementation with swertiamarin can attenuate weight gain and hepatic steatosis, improve glucose intolerance, oxidative stress, and insulin resistance, enhance insulin signaling, increase lipolysis, reduce adipocyte hypertrophy and macrophage infiltration, and alleviate obesity-associated inflammation by suppressing activation of the p38 MAPK and NF-kappa B pathways in obese mice fed with a high-fat diet.

ADIPOCYTE (2021)

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Article Cardiac & Cardiovascular Systems