4.4 Article

Mucosal Infection with Unmasked Candida albicans Cells Impacts Disease Progression in a Host Niche-Specific Manner

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Microbiology

Plasma Membrane Phosphatidylinositol-4-Phosphate Is Not Necessary for Candida albicans Viability yet Is Key for Cell Wall Integrity and Systemic Infection

Rocio Garcia-Rodas et al.

Summary: This study reveals that plasma membrane PI(4)P plays a central role in filamentation, cell wall integrity, and virulence in Candida albicans.
Article Microbiology

Control of β-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence

Mengli Yang et al.

Summary: Candida albicans, a major opportunistic pathogen, can switch between different forms and regulate immune recognition during morphogenesis. This study reveals that two highly expressed yeast proteins, Eng1 and Ywp1, mask beta-glucan in the cell wall, but beta-glucan is exposed during yeast-to-hypha transition. The expression of Eng1 is dynamically regulated in response to different carbon sources and antifungal drugs. The eng1 mutant modulates virulence in a sex and Dectin-1-dependent manner in a mouse model of disseminated candidiasis. These findings highlight the importance of beta-glucan exposure in modulating the balance between immune protection and immunopathogenesis during candidiasis.

PLOS PATHOGENS (2022)

Article Immunology

Economic Burden of Fungal Diseases in the United States

Kaitlin Benedict et al.

Summary: Conservatively estimated, the U.S. economic burden of fungal diseases in 2019 was $11.5 billion, including direct medical costs, productivity loss, and premature deaths. An alternative approach showed a value of over $48 billion. These estimates are likely low due to underdiagnosis and underreporting.

OPEN FORUM INFECTIOUS DISEASES (2022)

Review Mycology

When Is It Appropriate to Take Off the Mask? Signaling Pathways That Regulate ss(1,3)-Glucan Exposure in Candida albicans

Tian Chen et al.

Summary: The exposure of (1,3)-glucan plays a crucial role in anti-fungal immunity, and changes in the levels of surface exposed (1,3)-glucan can be induced by environmental stimuli and stressors within the host. Understanding the signal transduction cascades that regulate the changes in (1,3)-glucan exposure is critical for future therapeutic development.

FRONTIERS IN FUNGAL BIOLOGY (2022)

Article Immunology

Sex Differences in Macrophage Responses to Obesity-Mediated Changes Determine Migratory and Inflammatory Traits

Kuan-Hui Ethan Chen et al.

Summary: This study demonstrates that male mice are more prone to accumulating macrophages in adipose tissues in obesity-induced inflammation, with higher levels of leptin in serum and adipose tissue. Both hyperlipidemia and hyperleptinemia contribute to male macrophage-specific migration, with increased FFA inducing leptin receptors and higher leptin causing migration.

JOURNAL OF IMMUNOLOGY (2021)

Article Immunology

Male Macrophages and Fibroblasts from C57/BL6J Mice Are More Susceptible to Inflammatory Stimuli

Maria Luisa Barcena et al.

Summary: The study found that in an inflammatory environment, male mice exhibited stronger polarization and activation of macrophages and cardiac fibroblasts compared to females, suggesting a significant role of sex in cardiac pathologies.

FRONTIERS IN IMMUNOLOGY (2021)

Article Microbiology

Activation of Cph1 causes ss(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner

Andrew S. Wagner et al.

Summary: Activation of the Cek1 MAPK pathway and unmasking of immunogenic cell wall epitope ss(1,3)-glucan by specific genetic mutations weaken the virulence of Candida albicans. Neutrophils play a critical role in the clearance of unmasked fungal cells.

PLOS PATHOGENS (2021)

Article Microbiology

Epitope Shaving Promotes Fungal Immune Evasion

Delma S. Childers et al.

Article Microbiology

EphA2 is an epithelial cell pattern recognition receptor for fungal beta-glucans

Marc Swidergall et al.

NATURE MICROBIOLOGY (2018)

Review Microbiology

Oropharyngeal Candidosis in HIV-Infected Patients - An Update

Shankargouda Patil et al.

FRONTIERS IN MICROBIOLOGY (2018)

Review Microbiology

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species

Sarah G. Whaley et al.

FRONTIERS IN MICROBIOLOGY (2017)

Article Microbiology

IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa

Simon Altmeier et al.

PLOS PATHOGENS (2016)

Review Immunology

Sex differences in immune responses

Sabra L. Klein et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Immunology

Echinocandin Resistance in Candida

David S. Perlin

CLINICAL INFECTIOUS DISEASES (2015)

Article Immunology

Human intestinal epithelial cells respond to β-glucans via Dectin-1 and Syk

Sarit Cohen-Kedar et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

Article Immunology

Role of Neutrophils in IL-17-Dependent Immunity to Mucosal Candidiasis

Anna R. Huppler et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Biochemical Research Methods

Mouse model of oropharyngeal candidiasis

Norma V. Solis et al.

NATURE PROTOCOLS (2012)

Review Immunology

Mucosal Immunity and Candida albicans Infection

David L. Moyes et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2011)

Article Multidisciplinary Sciences

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Junko Yano et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2011)

Review Microbiology

Epidemiology of Invasive Mycoses in North America

Michael A. Pfaller et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2010)

Article Biochemistry & Molecular Biology

Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles

Robin van Bruggen et al.

MOLECULAR IMMUNOLOGY (2009)

Article Immunology

Immune recognition of candida albicans β-glucan by dectin-1

Neil A. R. Gow et al.

JOURNAL OF INFECTIOUS DISEASES (2007)

Article Immunology

Dectin-1 promotes fungicidal activity of human neutrophils

Adam D. Kennedy et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

Article Microbiology

A drug-sensitive genetic network masks fungi from the immune system

Robert T. Wheeler et al.

PLOS PATHOGENS (2006)

Review Infectious Diseases

Management of candida species infections in critically ill patients

P Eggimann et al.

LANCET INFECTIOUS DISEASES (2003)

Article Immunology

Dectin-1 is a major β-glucan receptor on macrophages

GD Brown et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

Review Immunology

Adjunctive immune therapy for fungal infections

A Casadevall et al.

CLINICAL INFECTIOUS DISEASES (2001)

Article Multidisciplinary Sciences

Immune recognition -: A new receptor for β-glucans

GD Brown et al.

NATURE (2001)

Article Biochemistry & Molecular Biology

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

S Krieger et al.

MOLECULAR MICROBIOLOGY (2000)