4.7 Article

Multi-strategy in production of high titer gluconic acid by the fermentation of concentrated cellulosic hydrolysate with Gluconobacter oxydans

期刊

INDUSTRIAL CROPS AND PRODUCTS
卷 189, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.indcrop.2022.115748

关键词

Gluconic acid; Enzymatic hydrolysate; Fermentation; Gluconobacter oxydans (G. oxydans)

资金

  1. National Natural Science Foundation of China [31901270]
  2. Postgraduate Research & Practice Innovation Program of Jiangsu Province [SJCX22_0324]
  3. Qing Lan Project of Jiangsu Province, China
  4. Start-up funds of Nanjing Forestry University for Scientific Research [163030163]
  5. Advanced Analysis and Testing Center of Nanjing Forestry University

向作者/读者索取更多资源

Efficiency of gluconic acid production from cellulosic materials can be improved through a combined strategy of activated carbon treatment and high-tension oxygen supply, enabling industrial-scale production.
Cellulosic hydrolysate from the hydrolysis of glucan-riched biomass can offer abundantly bioavailable glucose, which is an alternative feedstock for gluconic acid production. In order to speed up the process of cellulosic-based gluconic acid synthesis industrialization, cost reduction by using efficient substrate in batch-fermentation with high yield and productivity is extremely important. However, enriched glucose obtained by concentrating enzymatic hydrolysate inevitably ascends the viscosity, resulting in a lower oxygen transfer rate that cannot meet the requirement of bio-oxidation with Gluconobacter oxydans, resulting in gluconic acid productivity decreased drastically once the glucose content in the concentrated enzymatic hydrolysate was over 240 g/L with corresponding viscosity over 4 mPa center dot s. In view of the above problems, a combined strategy of activated carbon treatment and high-tension oxygen supply was applied to improve efficiency. Finally, approximately 230 g/L gluconic acid with 9.6 g/L/h productivity was achieved, which enabled the industrial-scale gluconic acid bioproduction from cellulosic materials.

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