Palladium-catalyzed site-selective C-H alkenylation of imidazo[2,1-b]thiazoles

Dehydrogenative alkenylation of imidazo[2,1-b]thiazoles via palladium(II)-catalyzed site-selective C-H bond activation has been developed in moderate to good yields under aerobic conditions. This methodology provides a very efficient, direct, and atomeconomical strategies to construct an alkenyl-imidazo [2,1-b]thiazole moiety. (C) 2016 Elsevier B.V. All rights reserved.