4.5 Review

Dendritic cells in energy balance regulation

期刊

IMMUNOLOGY LETTERS
卷 253, 期 -, 页码 19-27

出版社

ELSEVIER
DOI: 10.1016/j.imlet.2022.12.002

关键词

Obesity; Dendritic cells; Adipose tissue; Homeostasis; Flt3l; cDC1

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This review summarizes the role of dendritic cells (DCs) in chronic metabolic inflammation and their function in maintaining metabolic tissue homeostasis.
Besides their well-known role in initiating adaptive immune responses, several groups have studied the role of dendritic cells (DCs) in the context of chronic metabolic inflammation, such as in diet-induced obesity (DIO) or metabolic-associated fatty liver disease. DCs also have an important function in maintaining metabolic tissue homeostasis in steady-state conditions. In this review, we will briefly describe the different DC subsets, the murine models available to assess their function, and discuss the role of DCs in regulating energy balance and maintaining tissue homeostasis.

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