期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 81, 期 15, 页码 6525-6534出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b01148
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资金
- NIPER-Kolkata
- CSIR
- IICB-CSIR [BSC-015, BSC 0206]
- DST-India [CS-03/2013]
- Bristol-Myers Squibb-USA
An efficient, highly regioselective, and scalable ruthenium-catalyzed o-aryl C-H mono-cyanation of N-aryl-7azaindoles to form N-(2-cyanoaryl)-7-azaindoles has been developed through N-directed ortho C-H activation using N-cyano-N-phenyl-p-toluenesulfonamide as cyanating reagent in the presence of AgOTf and NaOAc in DCE. A range of substrates has furnished cyanated azaindoles in good to excellent yields under the simple reaction conditions. Involvement of C-H metalation has been supported by a kinetic study. This methodology provides easy access to a class of pharmaceutically significant molecules and their precursors.
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