期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 81, 期 11, 页码 4898-4905出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00818
关键词
-
资金
- National Natural Science Foundation of China [21332005, 21472085]
- Qing Lan Project
An Ir(III)-catalyzed direct C-H amidation/cyclization of benzamides using 2,2,2-trichloroethoxycarbonyl azide (TrocN3) as the aminocarbonyl source is reported. With the aid of cesium carboxylate, the reactions proceed efficiently and with high regioselectivity, producing various functionalized quinazoline-2,4(1H,3H)-diones, which are important building blocks and key synthetic intermediates for biologically and medicinally important compounds. During the reactions, two new C-N bonds were formed by breaking C-H and N-H bonds sequence.
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