期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 81, 期 14, 页码 5866-5877出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00554
关键词
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资金
- Max-Planck Society
- ERC Advanced Grant (AUTOHEPARIN)
Lactotetraosyl (Lc4) and neo-lactotetraosyl (nLc4) are backbones that are common to many glycans. Using automated glycan assembly, these common core structures were constructed and elaborated to access synthetically challenging glycans of biological relevance. The incorporation of alpha-fucoses is demonstrated for H-type I and II; alpha(1,3)-galactose epitopes were prepared, and the pentasaccharide HNK-1 required incorporation of a 3-O-sulfate. In addition to preparing the target structures, essential insights were gained regarding the relationships of glycosylating agents and nucleophiles as well as the linker stability.
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