期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 1, 页码 512-520出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02548
关键词
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资金
- National Natural Science Foundation of China [21472106, 21272132]
- National Key Basic Research Program of China (973 program) [2012CB933402]
Rh(III)-catalyzed substrate-controlled transformation of azobenzenes to indazoles and 2-acyl (NH) indoles is achieved via C-H functionalization. Generally, good functional groups tolerance, satisfying yields, and excellent regio-selectivity are achieved in this reaction. Mechanistically, the reaction with acrylates undergoes beta-hydride elimination, while the reaction with vinyl ketones or acrylamides undergoes nucleophilic addition. Copper acetate was supposed to play different roles in the beta-hydride elimination to furnish indazoles and nucleophilic addition of C-Rh bond to deliver 2-acyl (NH) indoles.
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