期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 81, 期 22, 页码 11514-11520出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02197
关键词
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资金
- National Natural Science Foundation of China [21406201]
- Special Program for Key Basic Research of the Ministry of Science and Technology of China [2014CB46060]
An Fe(III)-catalyzed solvent-free cross-dehydro-genative coupling of 3-benzylic indoles and compounds with acidic methylene groups has been achieved under high-speed ball milling (HSBM) conditions at room temperature. The reactions afford desired 3-arylmethylindole derivatives in moderate to high yields within 21 min of grinding. Besides, both N-substituted and N-free indoles can take part in this mechanochemical reaction as efficient nucleophiles to give bisindoles with satisfactory results. Remarkably, this protocol displays the possibility to induce high activity when using iron catalysts under HSBM conditions.
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