期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 81, 期 4, 页码 1681-1688出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00078
关键词
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资金
- NSFC [21372002, 21232007]
- PAPD of Jiangsu province
- Qing Lan Project
An enantioselective [4 + 2] cycloaddition of o-hydroxylstyrenes with azlactones has been established by merging chiral Bronsted acid (chiral phosphoric acid) and base (chiral guanidine) catalysis, which constructed a biologically important dihydrocoumarin scaffold in an efficient and enantioselective style (up to 99% yield, 96:4 er). This approach has not only realized the successful application of o-hydroxylstyrenes as oxa-diene precursors in catalytic asymmetric cycloadditions but also established a new cooperative catalytic system of chiral phosphoric acid and chiral guanidine.
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