期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 81, 期 9, 页码 3942-3950出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00466
关键词
-
资金
- GlaxoSmithKline
The Chan-Evans-Lam reaction is a valuable C-N bond forming process. However, aryl boronic acid pinacol (BPin) ester reagents can be difficult coupling partners that often deliver low yields, in particular in reactions with aryl amines. Herein, we report effective reaction conditions for the Chan-Evans-Lam amination of aryl BPin with alkyl and aryl amines. A mixed MeCN/EtOH solvent system was found to enable effective C-N bond formation using aryl amines while EtOH is not required for the coupling of alkyl amines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据