4.7 Article

Amount of Pannexin 1 in Smooth Muscle Cells Regulates Sympathetic Nerve-Induced Vasoconstriction

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids

Maki Kuzuya et al.

Summary: In this study, the cryo-EM structures of human PANX1 in lipid nanodiscs were analyzed to elucidate the gating mechanism and its regulation by the amino terminus in phospholipids. The results showed that the amino-terminal domain plays an essential role in channel opening and is associated with lipid movement.

SCIENCE SIGNALING (2022)

Article Peripheral Vascular Disease

Is the Pannexin-1 Channel a Mechanism Underlying Hypertension in Humans? a Translational Study of Human Hypertension

Lasse Gliemann et al.

Summary: Contrary to the hypothesis, the study shows that Pannexin-1 does not contribute to elevated blood pressure in essential hypertension in humans, which opposes the findings in preclinical models.

HYPERTENSION (2022)

Review Physiology

Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle

Susan Wray et al.

Summary: This study explores the mechanisms of calcium-activated chloride channels in smooth muscle tissues and the differences in their activation and regulation in different types of smooth muscles. The findings suggest that the expression and functional importance of CaCC vary in different smooth muscle tissues, with more complexity in activation and regulation observed in vascular smooth muscles.

FRONTIERS IN PHYSIOLOGY (2021)

Article Immunology

Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation

Christopher B. Medina et al.

Summary: The nucleotide release channel Panx1 plays an immunoregulatory role in T cell crosstalk during allergic airway inflammation, aiding in the suppression of disease progression. Mechanistic studies have shown the importance of Panx1-dependent Treg:Teff cell communication in restricting airway disease.

IMMUNITY (2021)

Article Multidisciplinary Sciences

Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Yu-Hsin Chiu et al.

Summary: Pannexin 1 (PANX1) ion channels are activated by G protein-coupled receptors (GPCRs), with alpha 1-adrenergic receptors (alpha 1-ARs) being one of the activators. The activation of PANX1 by alpha 1-ARs involves a non-canonical pathway that includes HDAC6-mediated lysine deacetylation of PANX1.

NATURE COMMUNICATIONS (2021)

Article Cardiac & Cardiovascular Systems

Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction

Nenja Kruger et al.

CIRCULATION RESEARCH (2020)

Article Multidisciplinary Sciences

Structures of human pannexin 1 reveal ion pathways and mechanism of gating

Zheng Ruan et al.

NATURE (2020)

Article Multidisciplinary Sciences

AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2

Maria Paz Prada et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane

Leon J. DeLalio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Hematology

Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure

Leon J. DeLalio et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone

Miranda E. Good et al.

CIRCULATION RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Purinergic Signaling in the Cardiovascular System

Geoffrey Burnstock

CIRCULATION RESEARCH (2017)

Article Pharmacology & Pharmacy

ATP is not involved in α1-adrenoceptor-mediated vasoconstriction in resistance arteries

James A. Angus et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

Article Multidisciplinary Sciences

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

Alexander W. Lohman et al.

NATURE COMMUNICATIONS (2015)

Article Endocrinology & Metabolism

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Samantha E. Adamson et al.

MOLECULAR METABOLISM (2015)

Article Hematology

Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction

Adam C. Straub et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Unexpected link between an antibiotic, pannexin channels and apoptosis

Ivan K. H. Poon et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region

Joanna K. Sandilos et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Neurosciences

Anoxia-Induced NMDA Receptor Activation Opens Pannexin Channels via Src Family Kinases

Nicholas L. Weilinger et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Physiology

Expression of Pannexin Isoforms in the Systemic Murine Arterial Network

Alexander W. Lohman et al.

JOURNAL OF VASCULAR RESEARCH (2012)

Article Biochemistry & Molecular Biology

Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis

Brian D. Gulbransen et al.

NATURE MEDICINE (2012)

Article Cardiac & Cardiovascular Systems

Pannexin1 Regulates α1-Adrenergic Receptor-Mediated Vasoconstriction

Marie Billaud et al.

CIRCULATION RESEARCH (2011)

Article Cell Biology

Probenecid, a gout remedy, inhibits pannexin 1 channels

William Silverman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Review Biochemistry & Molecular Biology

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

Gennady G. Yegutkin

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)

Article Cardiac & Cardiovascular Systems

P2X1 receptors mediate sympathetic postjunctional Ca2+ transients in mesenteric small arteries

Christine Lamont et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Pannexin membrane channels are mechanosensitive conduits for ATP

L Bao et al.

FEBS LETTERS (2004)