期刊
HISTOPATHOLOGY
卷 82, 期 6, 页码 794-811出版社
WILEY
DOI: 10.1111/his.14845
关键词
bone; FOS; GNAS; H3; 3; IDH; immunohistochemistry; MDM2; molecular
This review provides a brief update on select bone tumours, including their molecular features and immunohistochemical correlates, as well as some tips to avoid common diagnostic pitfalls.
Primary bone tumours can pose diagnostic problems due to their overlapping radiologic and histologic features. Given the recent advancement in our understanding of the biology of bone tumours, multiple immunohistochemical and molecular markers have been devised to aid in their diagnosis. This review provides brief updates on select bone tumours, including chondrosarcomas, benign chondrogenic tumours, osteosarcomas, benign osteogenic tumours, fibroosseous lesions, vascular tumours, osteoclastic giant cell-rich or cystic tumours, chordoma, adamantinoma, small round blue cell sarcomas, and others. We discuss their salient molecular features and novel immunohistochemical correlates, along with some tips to avoid common diagnostic pitfalls.
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