期刊
JOURNAL OF ORAL PATHOLOGY & MEDICINE
卷 46, 期 5, 页码 387-392出版社
WILEY
DOI: 10.1111/jop.12522
关键词
antioxidant capacity; burning mouth syndrome; markers of oxidative stress; oral lichen planus; saliva
资金
- Program 'Juan de la Cierva' of 'Ministerio de Economia y Competitividad', Spain
- Seneca Foundation of Murcia Region [19894/GERM/15]
ObjectivesThe aim of this study was to evaluate oxidative stress factors and C-reactive protein in the saliva of patients with oral lichen planus (OLP) and burning mouth syndrome (BMS). MethodsThis consecutive, cross-sectional study included 20 patients with OLP, 19 with burning mouth syndrome (BMS), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire (OHIP-14) and the xerostomia inventory. The following parameters were measured in whole non-stimulated saliva: trolox equivalent antioxidant capacity (TEAC); total antioxidant capacity (TAC); cupric reducing antioxidant capacity (CUPRAC); ferric reducing ability of plasma (FRAP); C-reactive protein (CRP); nitric oxide; nitrates; and nitrites. ResultsThe OLP group presented statistically significant differences in reactive oxygen species (ROS) (29 600 cps) in comparison with the control group (39 679 cps) (P < 0.05). In the BMS group, ROS was 29 707 cps with significant difference in comparison with the control group (P < 0.05). Significantly higher salivary nitric oxide (145.7 mol) and nitrite (141.0 mol) levels were found in OLP patients in comparison with control group (P < 0.05). ConclusionIncreases in nitric oxide and C-reactive protein were found in the saliva of OLP patients in comparison with BMS and control patients. Further studies are required to confirm these findings.
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