期刊
HELICOBACTER
卷 28, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/hel.12947
关键词
dual therapy; Helicobacter pylori infection; tetracycline; vonoprazan
This study evaluated the eradication rate and adverse effects of vonoprazan and tetracycline dual therapy as first-line and rescue treatment regimens for special populations with penicillin allergy or failed in previous amoxicillin-containing therapies. The results showed that this combination therapy was effective and safe in treating Helicobacter pylori infection in special populations.
BackgroundThe treatment of Helicobacter pylori (H. pylori) infection is a challenge for those who cannot use amoxicillin. ObjectiveTo evaluate the eradication rate and adverse effects of vonoprazan and tetracycline dual therapy as first-line and rescue treatment regimens used in special populations with penicillin allergy or failed in previous amoxicillin-containing therapies. DesignPatients enrolled were those who were H. pylori-positive with selected conditions: (1) allergic to penicillin, either naive to treatment or had failed before; or (2) failed in previous amoxicillin-containing therapies. All enrolled patients accepted 14-day vonoprazan and tetracycline dual therapy (VT dual therapy) as follows: vonoprazan (20 mg b.i.d.) and tetracycline (500 mg t.i.d. [body weight < 70 kg] or 500 mg q.i.d. [body weight >= 70 kg]). H. pylori status was evaluated by C-13-urease breath test 6 weeks after treatment. All adverse effects were recorded. Some patients underwent bacterial culture and antibiotic susceptibility testing. ResultsA total of 62 patients were enrolled; 18 of them received VT dual therapy as first-line treatment, 44 patients received VT dual therapy as rescue treatment. Overall, 58 of 62 patients achieved successful eradication (93.5%), while all involved (100%,18/18) succeeded in the first-line treatment group and 40 cases (90.9%, 40/44) succeeded in the rescue treatment group. Sixty-one (61/62, 98.4%) patients completed the whole course of treatment. Adverse events occurred in 6 patients (6/62, 9.7%), while one patient quit because of skin rash. All adverse effects were mild and relieved spontaneously after H. pylori treatment. Five patients achieved successful H. pylori culture, and all strains isolated were sensitive to tetracycline. ConclusionsFor the treatment of H. pylori infection in special populations with penicillin allergy or failed in previous amoxicillin-containing therapies, a 14-day vonoprazan and tetracycline dual therapy was effective and safe as first-line and rescue treatment in our study. Further study is warranted to verify its efficacy, especially for those who cannot use amoxicillin.
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