Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination

Article Gastroenterology & Hepatology

Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events

Siew C. Ng et al.

Summary: This study identified specific gut microbiota markers associated with improved immune response and reduced adverse events following COVID-19 vaccines, suggesting that microbiota-targeted interventions may complement the effectiveness of vaccines.

GUT (2022)

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Article Immunology

SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens

Laurent Bartolo et al.

Summary: The baseline composition of T cells has a direct impact on the response to pathogens, and the precursor states of these cells are complex and not well defined. This study examined the baseline state of T cells specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in prepandemic blood samples. The data revealed a diverse range of preexisting memory states in these cells, with distinct features and potential for trafficking to barrier tissues. The study also found cross-reactivity between T cell clones and antigens from commensal bacteria, highlighting the importance of noninfectious exposures to shaping preexisting immunity to SARS-CoV-2.

SCIENCE IMMUNOLOGY (2022)

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Article Food Science & Technology

The intestinal microbiota and improving the efficacy of COVID-19 vaccinations

Jiezhong Chen et al.

Summary: Most COVID-19 cases are mild or asymptomatic with effective immune responses, but a minority can develop severe disease due to imbalances in the immune system. Vaccines have been developed to provide protection or reduce severity of the disease, but there is a need for improved efficacy and safety. Gut dysbiosis and modulation of gut microbiota through functional foods may play a role in vaccine ineffectiveness and adverse effects in COVID-19.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Immunology

CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients

Vamsee Mallajosyula et al.

Summary: The study suggests that CD8(+) T cells with conserved specificities are more abundant in COVID-19 patients with mild disease, indicating a potential protective role.

SCIENCE IMMUNOLOGY (2021)

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Editorial Material Immunology