This report demonstrates a light-promoted water-mediated NBS photoinitiated cleavage method for electron-deficient conjugated alkenes under mild and greener conditions via the hydrogen atom transfer mechanism. Additionally, this methodology is shown to work as a deprotection step for carbonyl groups. The protocol exhibits wide range of functional group tolerance and high regioselectivity at room temperature in an aqueous medium.
Deconstruction of alkenes to their carbonyl derivatives is a widely used protocol in synthetic organic chemistry and several reaction conditions have been demonstrated for electron-rich and unconjugated alkenes. However, such reactions of electron-deficient and conjugated alkenes are highly challenging. In this report, we have demonstrated a light-promoted water-mediated NBS photoinitiated cleavage of electron-deficient conjugated alkenes under mild and greener conditions via the hydrogen atom transfer mechanism. Additionally, this methodology is demonstrated as a deprotection step for carbonyl groups. This protocol works at room temperature in an aqueous medium with a wide range of functional group tolerance and high regioselectivity.
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