Electrochemical primary amination of imidazopyridines with azidotrimethylsilane under mild conditions

A straightforward protocol involving electrochemical primary amination of imidazopyridines under mild conditions is described. This transformation utilizes TMSN3 as the nitrogen source and a trace amount of H2O as the hydrogen source. A wide range of imidazopyridines were found to be compatible, providing the corresponding C3-amino substituted imidazopyridines in moderate to good yields.

Automated summary

A straightforward protocol for the electrochemical primary amination of imidazopyridines has been developed. This transformation utilizes TMSN3 as the nitrogen source and a trace amount of H2O as the hydrogen source. A wide range of imidazopyridines are compatible, providing the corresponding C3-amino substituted imidazopyridines in moderate to good yields.