Catalyst-free access to aryldifluoromethyl ketones has been achieved through decarboxylative arylation of alpha,alpha-difluoro-beta-ketoacid salts using diaryliodonium(iii) salts. The products were successfully transformed into the corresponding esters, amides, and difluoromethyl compounds. This strategy provides access to fluorine-containing drugs, thus contributing to drug design.
Catalyst-free access to aryldifluoromethyl ketones has been achieved through decarboxylative arylation of alpha,alpha-difluoro-beta-ketoacid salts using diaryliodonium(iii) salts. The products were successfully transformed into the corresponding esters, amides, and difluoromethyl compounds. This strategy provides access to fluorine-containing drugs, thus contributing to drug design.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据