期刊
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
卷 261, 期 7, 页码 1871-1881出版社
SPRINGER
DOI: 10.1007/s00417-023-05982-w
关键词
Age-related macular degeneration; Injection frequency; Intravitreal aflibercept injection; Macular atrophy; Long-term observation
The study aimed to investigate the 7-year best-corrected visual acuity (BCVA) course of neovascular age-related macular degeneration (nAMD) patients after a 1-year fixed regimen of intravitreal aflibercept injection (IVA). The results showed that the BCVA in nAMD patients could be maintained for 7 years after the 1-year fixed regimen of IVA, emphasizing the importance of early diagnosis and treatment for long-term good visual outcomes.
Purpose The study aims to investigate the 7-year best-corrected visual acuity (BCVA) course after 1-year fixed regimen of intravitreal aflibercept injection (IVA) for neovascular age-related macular degeneration (nAMD) and to identify factors affecting this BCVA.Methods This longitudinal, observational study included 63 treatment-naive eyes (61 patients) with nAMD, treated with 1-year fixed regimen of IVA-3 monthly injections and 4 subsequent bimonthly injections-essentially followed by PRN regimen of IVA but sometimes followed by agent switching, photodynamic therapy (PDT), or vitrectomy, as needed. We assessed BCVA changes over a 7-year period. Morphologically, we assessed central retinal thickness (CRT), central choroidal thickness (CCT), subfoveal pigment epithelial detachment (PED) height, vitreomacular traction/adhesion (VMT/VMA), epiretinal membrane (ERM), and macular atrophy involving the fovea.Results Logarithm of the minimum angle of resolution (logMAR) BCVA changed from 0.20 +/- 0.24 to 0.29 +/- 0.45 over 7 years. BCVA improved significantly after years 1 and 2 (P = 0.002 and 0.001, respectively) and then slowly decreased. BCVA after years 3-7 did not significantly differ from baseline. CRT and CCT decreased significantly during follow-up, while PED height did not. VMT/VMA decreased significantly, whereas ERM and macular atrophy increased significantly. Seven-year and baseline BCVA positively correlated (P = 0.007, beta = 0.35).Conclusions BCVA was maintained for 7 years in nAMD eyes after 1-year fixed regimen of IVA, essentially followed by PRN regimen, but sometimes followed by agent switching, PDT, or vitrectomy, without severe drug-induced complications. Thus, early diagnosis and treatment of nAMD are essential for maintaining good long-term BCVA, even in eyes with relatively poor baseline vision.
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