NR4A3 fusions characterize a distinctive peritoneal mesothelial neoplasm of uncertain biological potential with pure adenomatoid/microcystic morphology

Article Oncology

A novel fusion variant LSM14A::NR4A3 in extraskeletal myxoid chondrosarcoma

Carine Ngo et al.

Summary: This study reports a case of calf EMC in a 34-year-old male and identifies a novel fusion transcript LSM14A::NR4A3, expanding the molecular spectrum of EMC.

GENES CHROMOSOMES & CANCER (2023)

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Article Pathology

Pleural mesothelioma classification-update and challenges

Sanja Dacic

Summary: This passage discusses the classification and grading of mesothelial tumors, emphasizing the importance for prognosis and treatment decisions. It also highlights recent changes in the WHO classification of pleural tumors, particularly focusing on the subtyping of epithelioid mesotheliomas.

MODERN PATHOLOGY (2022)

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Review Oncology

Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations

Michele Carbone et al.

Summary: The most common malignancies that develop in carriers of BAP1 germline mutations include mesothelioma, melanoma, renal cell carcinoma, and other tumor types. The features of malignancies can vary among individuals, and a multidisciplinary approach is required for diagnosis and treatment. Detecting BAP1 germline mutations has significant medical, social, and economic impact.

JOURNAL OF THORACIC ONCOLOGY (2022)

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Review Medicine, General & Internal

Adenomatoid mesothelioma arising from the diaphragm: a case report and review of the literature

Kenta Kawabe et al.

Summary: This report presents a rare case of adenomatoid mesothelioma that developed on the peritoneal surface of the diaphragm, as well as a literature review of adenomatoid mesothelioma in the abdominal cavity. It highlights the need to reclassify adenomatoid mesothelioma and adenomatoid tumors and emphasizes the importance of accumulating and sharing new findings to clarify the clinicopathological characteristics and genetic status of adenomatoid mesothelioma.

JOURNAL OF MEDICAL CASE REPORTS (2022)

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Article Pathology

Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases

Anais Malpica et al.

Summary: Localized malignant peritoneal mesothelioma is a rare tumor with limited information available. This study presents the experience with 18 cases seen in a hospital over a period of 43 years. Most patients were Caucasians, and the main symptom was abdominal pain. Microscopic examination revealed typical malignant mesothelioma features in most cases, but some cases had mixed features. Some patients had a history of asbestos exposure, and a family history of tumors was common. The majority of patients underwent surgery, and some also received adjuvant chemotherapy. The mean overall survival was 80.4 months, with a 3-year survival rate of 79% and a 5-year survival rate of 52.6%. Limited sample data suggest that small tumor size, low-grade cytology, and low mitotic index may be associated with a benign behavior.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2022)

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Article Oncology

EWSR1::YY1 fusion positive peritoneal epithelioid mesothelioma harbors mesothelioma epigenetic signature: Report of 3 cases in support of an emerging entity

Josephine K. Dermawan et al.

Summary: Our study presents three additional cases of peritoneal mesotheliomas with EWSR1::YY1 fusions, which are rare malignant tumors occurring in middle-aged adults without asbestos exposure history. Pathological and immunohistochemical analysis confirmed the characteristics of this new type of mesothelioma.

GENES CHROMOSOMES & CANCER (2022)

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Article Pathology

Solid-Tubulocystic Variant of Intrahepatic Cholangiocarcinoma: Report of a Pediatric Case With Molecular Characterization

Ivan A. Gonzalez et al.

Summary: This case presents a rare variant of intrahepatic cholangiocarcinoma in a young girl, expanding the reported age range of this tumor type. The study confirms a recently-reported diagnostic genomic alteration and stresses the importance of awareness of this rare entity affecting pediatric patients to avoid confusion with similar-appearing neoplasms.

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY (2022)

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Article Oncology

Molecular Characterization of Mesothelioma: Impact of Histologic Type and Site of Origin on Molecular Landscape

Ibiayi Dagogo-Jack et al.

Summary: Large-scale molecular analysis of mesothelioma and its subtypes reveals the molecular characteristics and differences of the disease, providing important information for future therapeutic strategies.

JCO PRECISION ONCOLOGY (2022)

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Article Pathology

Pediatric Mesothelioma With ALK Fusions A Molecular and Pathologic Study of 5 Cases

Pedram Argani et al.

Summary: Pediatric mesotheliomas are rare, and this study reports 5 cases of malignant mesothelioma in children, characterized by fusions involving the ALK gene. The cases showed classic morphologic and immunohistochemical features of malignant mesothelioma, with ALK gene rearrangements investigated through molecular methods. These ALK-rearranged mesotheliomas share similarities with other fusion-positive mesotheliomas, occurring in young patients and having a simple, translocation-driven genetic profile.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

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Article Cell Biology

Identification of EWSR1-NFATC2 fusion in simple bone cysts

Yin P. Hung et al.

Summary: Simple bone cysts are benign intramedullary tumors mainly involving long bones in skeletally immature individuals. Some may resemble other tumors, but genetic analysis can aid in differentiation. Detection of EWSR1 and/or FUS rearrangements may help distinguish simple bone cysts from mimics.

HISTOPATHOLOGY (2021)

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Article Pathology

A Novel NIPBL-NACC1 Gene Fusion Is Characteristic of the Cholangioblastic Variant of Intrahepatic Cholangiocarcinoma

Pedram Argani et al.

Summary: A novel NIPBL-NACC1 gene fusion was identified in a rare primary hepatic neoplasm, leading to distinct morphological and immunophenotypic features of the tumor.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

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Article Oncology

SMARCA2-NR4A3 is a novel fusion gene of extraskeletal myxoid chondrosarcoma identified by RNA next-generation sequencing

Shuanzeng Wei et al.

Summary: Extraskeletal myxoid chondrosarcoma (EMC) is a rare sarcoma with uncertain differentiation, commonly involving chromosomal translocation of NR4A3. This report describes a patient with EMC at the dorsum of the right foot, showing a characteristic fusion gene and expression of various markers in tumor cells. The tumor cells expressed synaptophysin, GFAP, and other markers, while being negative for some others.

GENES CHROMOSOMES & CANCER (2021)

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Article Pathology

Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients

Hezhen Ren et al.

Summary: This article presents two pediatric cases of EWSR1-ATF1 translocation-associated malignant mesothelioma in the peritoneum and pericardium, both lacking a known exposure history. Microscopic examination revealed predominantly epithelioid morphology with positive immunohistochemistry results, and RNA sequencing confirmed EWSR1-ATF1 gene rearrangement in both cases.

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY (2021)

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Article Oncology

Anaplastic Lymphoma Kinase Gene Rearrangement in Children and Young Adults With Mesothelioma

Idrees Mian et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

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Article Pathology

Malignant Diffuse Mesothelioma in Women A Study of 354 Cases

Elizabeth N. Pavlisko et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2020)

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Article Anatomy & Morphology

BAP1 Loss is a Useful Adjunct to Distinguish Malignant Mesothelioma Including the Adenomatoid-like Variant From Benign Adenomatoid Tumors

Ramona Erber et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2020)

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Article Oncology

Molecular Profiling of Atypical Tenosynovial Giant Cell Tumors Reveals Novel Non-CSF1 Fusions

Theodore Vougiouklakis et al.

CANCERS (2020)

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Article Oncology

NTRK and ALK rearrangements in malignant pleural mesothelioma, pulmonary neuroendocrine tumours and non-small cell lung cancer

Jose Luis Leal et al.

LUNG CANCER (2020)

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Review Pathology

Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description

Georgia Karpathiou et al.

ADVANCES IN ANATOMIC PATHOLOGY (2020)

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Article Pathology

EWSR1/FUS-CREBfusions define a distinctive malignant epithelioid neoplasm with predilection for mesothelial-lined cavities

Pedram Argani et al.

MODERN PATHOLOGY (2020)

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Article Pathology

Peritoneal adenomatoid (microcystic) mesothelioma

Daisuke Mori et al.

PATHOLOGY INTERNATIONAL (2020)

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Review Cell Biology

Roles of NIPBL in maintenance of genome stability

Danyan Gao et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

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Article Pathology

Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands

Florian Haller et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2019)

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Letter Pathology

NR4A3 Immunohistochemistry Lacks Sensitivity for the Diagnosis of Extraskeletal Myxoid Chondrosarcoma

Ana C. Vargas et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2019)

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Article Multidisciplinary Sciences

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands

Florian Haller et al.

NATURE COMMUNICATIONS (2019)

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Article Pathology

Adenomatoid tumors of the male and female genital tract are defined by &ITTRAF7&IT mutations that drive aberrant NF-kB pathway activation

Benjamin Goode et al.

MODERN PATHOLOGY (2018)

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Article Medical Laboratory Technology

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group

Aliya Noor Husain et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2018)

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Article Oncology

Identification of ALK Rearrangements in Malignant Peritoneal Mesothelioma

Yin P. Hung et al.

JAMA ONCOLOGY (2018)

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Article Oncology

Integrative Molecular Characterization of Malignant Pleural Mesothelioma

Jutija Hmeljaki et al.

CANCER DISCOVERY (2018)

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Article Oncology

Co-occurring Mutations of Tumor Suppressor Genes, LATS2 and NF2, in Malignant Pleural Mesothelioma

Robin Tranchant et al.

CLINICAL CANCER RESEARCH (2017)

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Article Pathology

Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X

Nancy M. Joseph et al.

MODERN PATHOLOGY (2017)

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Article Oncology

HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma

Milena Urbini et al.

GENES CHROMOSOMES & CANCER (2017)

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Article Oncology

BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas

Noemie Leblay et al.

JOURNAL OF THORACIC ONCOLOGY (2017)

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Article Pathology

A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions

Patrice Desmeules et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2017)

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Article Pathology

A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases

Rita Alaggio et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2016)

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Article Genetics & Heredity

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

Raphael Bueno et al.

NATURE GENETICS (2016)

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Article Cell Biology

A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome

Anthony D. Schmitt et al.

CELL REPORTS (2016)

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Article Oncology

Novel TNS3-MAP3K3 and ZFPM2-ELF5 fusion genes identified by RNA sequencing in multicystic mesothelioma with t(7;17)(p12;q23) and t(8;11)(q23;p13)

Ioannis Panagopoulos et al.

CANCER LETTERS (2015)

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Article Cell Biology

The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer

Jordan A. Beard et al.

CELLULAR SIGNALLING (2015)

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Article Oncology

Hippo Pathway Gene Mutations in Malignant Mesothelioma Revealed by RNA and Targeted Exon Sequencing

Akihiko Miyanaga et al.

JOURNAL OF THORACIC ONCOLOGY (2015)

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Article Medicine, Research & Experimental

BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma

Hakan Alakus et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

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Review Biochemistry & Molecular Biology

NR4A nuclear receptors are orphans but not lonesome

Kondababu Kurakula et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

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Article Pathology

Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology

Narasimhan P. Agaram et al.

HUMAN PATHOLOGY (2014)

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Article Oncology

Extraskeletal myxoid chondrosarcoma with a t(9;16)(q22;p11.2) resulting in a NR4A3-FUS fusion

Cory J. Broehm et al.

CANCER GENETICS (2014)

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Article Pathology

Microcystic variant malignant mesothelioma presenting as a localized paraspinal mass

Hyang Mi Ko et al.

CYTOJOURNAL (2014)

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Article Oncology

RNA sequencing identifies fusion of the EWSR1 and YY1 genes in mesothelioma with t(14;22)(q32;q12)

Ioannis Panagopoulos et al.

GENES CHROMOSOMES & CANCER (2013)

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Article Pathology

Mesothelioma with signet-ring cell features: report of 23 cases

Nelson G. Ordonez

MODERN PATHOLOGY (2013)

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Letter Oncology

Identification of NIPBL, a new ETV6 partner gene in t(5;12) (p13;p13)-associated acute megakaryoblastic leukemia

Etienne De Braekeleer et al.

LEUKEMIA & LYMPHOMA (2013)

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Article Pathology

Malignant mesothelioma with prominent adenomatoid features: a clinicopathologic and immunohistochemical study of 10 cases

Annikka Weissferdt et al.

ANNALS OF DIAGNOSTIC PATHOLOGY (2011)

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Letter Biotechnology & Applied Microbiology

Integrative genomics viewer

James T. Robinson et al.

NATURE BIOTECHNOLOGY (2011)

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Article Multidisciplinary Sciences

Second Generation Sequencing of the Mesothelioma Tumor Genome

Raphael Bueno et al.

PLOS ONE (2010)

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Article Oncology

The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene

C. Filion et al.

JOURNAL OF PATHOLOGY (2009)

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Article Pathology

Histologic Assessment and Prognostic Factors of Malignant Pleural Mesothelioma Treated With Extrapleural Pneumonectomy

Andrea V. Arrossi et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2008)

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Article Immunology

Multiple extragenital adenomatoid tumors in the mesocolon and omentum

Chi-Ju Yeh et al.

APMIS (2008)

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Article Biochemistry & Molecular Biology

Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

Shannon E. Mullican et al.

NATURE MEDICINE (2007)

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Article Pathology

Multiple adenomatoid tumours in the liver and peritoneum

Stephen J. Hayes et al.

JOURNAL OF CLINICAL PATHOLOGY (2007)

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Article Cardiac & Cardiovascular Systems

Neuron-derived orphan receptor-1 (NOR-1) modulates vascular smooth muscle cell proliferation

J Martínez-González et al.

CIRCULATION RESEARCH (2003)

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Article Pathology

Microcystic variant of localized malignant mesothelioma accompanying an adenomatoid tumor-like lesion

H Umezu et al.

PATHOLOGY INTERNATIONAL (2002)

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Article Biochemistry & Molecular Biology

The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing

N Ohkura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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NR4A3 fusions characterize a distinctive peritoneal mesothelial neoplasm of uncertain biological potential with pure adenomatoid/microcystic morphology

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