Clear cell mesotheliomas with inactivating VHL mutations and near-haploid genomic features

Article Pathology

Sclerosing Polycystic Adenoma of Salivary Glands A Novel Neoplasm Characterized by PI3K-AKT Pathway Alterations-New Insights Into a Challenging Entity

Alena Skalova et al.

Summary: Sclerosing polycystic adenoma (SPA) is a rare salivary gland tumor that can develop intraluminal epithelial proliferation with different cytomorphologic characteristics, and it has specific molecular alterations.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2022)

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Article Oncology

Molecular Characterization of Peritoneal Mesotheliomas

Michael Offin et al.

Summary: Malignant peritoneal mesothelioma (MPeM) has distinct biology and genomic composition. BAP1 alteration/loss is associated with shorter survival, and a minority of specimens had genomic near-haploidization (GNH) associated with specific mutations. Pathogenic germline mutations were found in 3 of 30 patients.

JOURNAL OF THORACIC ONCOLOGY (2022)

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Article Oncology

EWSR1::YY1 fusion positive peritoneal epithelioid mesothelioma harbors mesothelioma epigenetic signature: Report of 3 cases in support of an emerging entity

Josephine K. Dermawan et al.

Summary: Our study presents three additional cases of peritoneal mesotheliomas with EWSR1::YY1 fusions, which are rare malignant tumors occurring in middle-aged adults without asbestos exposure history. Pathological and immunohistochemical analysis confirmed the characteristics of this new type of mesothelioma.

GENES CHROMOSOMES & CANCER (2022)

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Article Oncology

Molecular Characterization of Mesothelioma: Impact of Histologic Type and Site of Origin on Molecular Landscape

Ibiayi Dagogo-Jack et al.

Summary: Large-scale molecular analysis of mesothelioma and its subtypes reveals the molecular characteristics and differences of the disease, providing important information for future therapeutic strategies.

JCO PRECISION ONCOLOGY (2022)

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Article Medicine, General & Internal

Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease

Eric Jonasch et al.

Summary: The HIF-2α inhibitor belzutifan showed efficacy in patients with renal cell carcinoma associated with von Hippel-Lindau disease, with nearly half of the patients having an objective response to treatment.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Clinicopathological characteristics of primary peritoneal epithelioid mesothelioma of clear cell type A case report

Xue-Mei Du et al.

Summary: Primary peritoneal epithelioid mesothelioma of clear cell type is a rare entity that requires differentiation from various clear cell tumors. It is characterized by specific genetic alterations, highlighting the importance of individualized therapy guidance. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy helps achieve long-term survival.

MEDICINE (2021)

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Article Pathology