期刊
GASTROENTEROLOGIA Y HEPATOLOGIA
卷 46, 期 10, 页码 774-783出版社
ELSEVIER ESPANA SLU
DOI: 10.1016/j.gastrohep.2023.01.012
关键词
Functional constipation; Defecatory dyssynergy; Anorrectal biofeedback; Fiber diet
This study aimed to evaluate the efficacy and safety of a high fiber diet in the treatment of patients with defecatory dyssynergy undergoing anorectal biofeedback. The results showed that a high fiber diet did not improve the effectiveness of anorectal biofeedback and was associated with a reduction in improvement of abdominal symptoms.
Introduction: Fiber is the initial treatment in chronic functional constipation. However, its role in the group of patients with defecatory dyssynergy is not well established. The objective of the study is to evaluate the efficacy and safety of a high fiber diet in patients with defecatory dyssynergy in the treatment with anorectal biofeedback. Patients and methods: An exploratory, randomized (1:1), double-blind, controlled add-on clinical trial was carried out in a reference center in Spain in patients with functional constipation and defecatory dyssynergy according to the ROME IV criteria. Control group: treatment with biofeedback and low-fiber diet (15-20 g/day). Experimental group: treatment with biofeedback and high fiber diet (25-30 g/day). Analyzed: responder (primary endpoint), patient whose defecatory dyssynergy had been corrected (> 20% reduction in anal pressure during the defecation maneuver and normal balloon expulsion test); anorectal parameters (anal relaxation, reduced straining); safety (abdominal symptoms: flatulence, pain, borborygmus, bloating). Results: A total of 44 patients were randomized: 22 per group. The percentage of responders was 75% (15/20; 95% CI: 53 89%) control group and 70% (14/20; 95% CI: 48-85%) experimental group, P =.225. Differences in favor of the control group were only observed in abdominal symptoms: flatulence (P =.028), abdominal distension (P =.041) and digestive comfort (P =.043). Conclusions: In patients with defecatory dyssynergy, a high-fiber diet not only does not improve the efficacy of anorectal biofeedback but is associated with a loss of improvement in abdominal symptoms. (c) 2023 Elsevier Espana, S.L.U. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据