期刊
FOOD RESEARCH INTERNATIONAL
卷 163, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.foodres.2022.112226
关键词
Lipid droplet; Metabolic disorders; Inulin; High-fat-diet; Gut microbiota; Fat loaded short-and long-term
Increased consumption of high-fat low-fiber foods is associated with the development of metabolic syndromes. Fermentable dietary fiber, such as inulin, can alleviate metabolic abnormalities. This study systematically investigated the effect of inulin on mice with metabolic disorders induced by short-term and long-term high-fat feeding. The results showed that inulin reduced body weight, improved glucose intolerance, and alleviated hepatic steatosis in both groups of mice, suggesting a potential mechanism mediated through the modulation of gut microbiota.
Increased consumption of high-fat low-fiber foods has been shown to contribute to the development of metabolic syndromes, such as fatty liver, obesity, diabetes, et al. Fermentable dietary fiber, such as inulin, is broadly used to mitigate host metabolic abnormalities. In this work, we studied systematically the effect of inulin on mice with metabolic disorders, induced by either short-or long-term high-fat feeding. As expected, inulin reduced the body weight of mice in both groups. However, it was found that inulin feeding could only increase energy expenditure, alleviate adiposity, and improve glucose intolerance in mice fed with high-fat diet (HFD) for 1 month but not for 4 months. Surprisingly, inulin supplementation could alleviate HFD-induced hepatic steatosis, mediated through increasing adipose triglyceride lipase (ATGL) on liver lipid droplets, in both groups. Gut microbiota in the short -and long-term fat-loaded mice were shown to be modulated differently, which may mediate the differential effects of inulin. These results may help in understanding the role and mechanism of fermentable fiber regulating host metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据