期刊
CATALYSIS TODAY
卷 247, 期 -, 页码 104-116出版社
ELSEVIER
DOI: 10.1016/j.cattod.2014.03.066
关键词
Aqueous reactions; Transfer hydrogenation; Asymmetric catalysis; pH effect; Biomass
资金
- DTI MMI project
- EPSRC
- Pfizer
- AstraZeneca
- University of Liverpool
- National Science Foundation of China [21103102]
- Distinguished Doctoral Research Fund of Shaanxi Normal University [S2011YB02]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT 1070]
- Cheung Kong Scholar Program
- Fundamental Research Funds for the Central Universities [GK261001095]
Transfer hydrogenation has become a versatile and practical method for reduction in organic synthesis. The development of aqueous transfer hydrogenation reactions is not only fundamentally interesting in terms of understanding enzymatic catalysis, but also offers economic and environmental benefits, as water is cheap and nontoxic. In this review paper, an account of the work on transfer hydrogenation in aqueous media done by the Xiao group is given. Aqueous transfer hydrogenation of ketones, aldehydes and heterocycles as well as reductive amination reactions, including extension into biomass-derived platform molecules, has been successfully developed employing the classical Noyori-type catalysts or the newly invented iridacycles, with most of the reactions taking place on water. Water is shown to be an enabling medium for transfer hydrogenation reactions of various features. Not only can it accelerate a reduction, it also provides a simple tool, the solution pH, to control a reaction. (C) 2014 Elsevier B.V. All rights reserved.
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