4.8 Article

Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems

期刊

ADVANCED MATERIALS
卷 27, 期 34, 页码 5080-+

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201501557

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  1. Exploratory Research for Advanced Technology of Japan Science and Technology Agency (JST-ERATO)
  2. Japanese Society for the Promotion of Science [26820361]
  3. Grants-in-Aid for Scientific Research [26820361] Funding Source: KAKEN

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A nanocarrier-integrated bottom-up method is a promising strategy for advanced drug-release systems. Self-assembled nanogels, which are one of the most beneficial nanocarriers for drug-delivery systems, are tectonically integrated to prepare nanogel-crosslinked (NanoClik) microspheres. NanoClik microspheres consisting of nanogel-derived structures (observed by STED microscopy) release drug-loaded nanogels after hydrolysis, resulting in successful sustained drug delivery in vivo.

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