期刊
FISH PHYSIOLOGY AND BIOCHEMISTRY
卷 48, 期 6, 页码 1665-1684出版社
SPRINGER
DOI: 10.1007/s10695-022-01146-5
关键词
Fish ontogeny; IGF-1R; Akt; Cellular signaling; Metabolism
资金
- European Union and Greek national funds through the National Strategic Reference Framework 2014-2020 (GR & EU), Special Actions Aquacul-ture-Industrial Materials-Open innovation in culture [MIS 5045873]
This study investigates the developmental stages-specific shift in critical signaling pathways of reared S. dumerili. The activation of IGF-1R plays an important role in mediating various developmental pathways, including hypertrophic signaling, MAPK phosphorylation, apoptosis, and autophagy. Furthermore, morphogenetic rearrangements and energy consumption were observed during the hatching process.
Cell growth and differentiation signals of insulin-like growth factor-1 (IGF-1), a key regulator in embryonic and postnatal development, are mediated through the IGF-1 receptor (IGF-1R), which activates several downstream pathways. The present study aims to address crucial organogenesis and development pathways including Akt, MAPKs, heat shock response, apoptotic and autophagic machinery, and energy metabolism in relation to IGF-1R activation during five developmental stages of reared Seriola dumerili: 1 day prior to hatching fertilized eggs (D-1), hatching day (D0), 3 days post-hatching larvae (D3), 33 (D33) and 46 (D46) days post-hatching juveniles. During both the fertilized eggs stage and larval-to-juvenile transition, IGF-1R/Akt pathway activation may mediate the hypertrophic signaling, while p44/42 MAPK phosphorylation was apparent at S. dumerili post-hatching processes and juvenile organs completion. On the contrary, apoptosis was induced during embryogenesis and autophagy at hatching day indicating a potential involvement in morphogenetic rearrangements and yolk-sac reserves depletion. Larvae morphogenesis was accompanied by a metabolic turnover with increased substantial energy consumption. The findings of the present study demonstrate the developmental stages-specific shift in critical signaling pathways during the ontogeny of reared S. dumerili.
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