4.7 Article

Dietary glycerol monolaurate protects Cherax quadricarinatus against white spot syndrome virus infection

期刊

FISH & SHELLFISH IMMUNOLOGY
卷 131, 期 -, 页码 1085-1091

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2022.11.014

关键词

Glycerol monolaurate (GML); Crayfish; Cherax quadricarinatus; White spot syndrome virus (WSSV); Innate immunity

资金

  1. Open Research Fund of Key Laboratory of Healthy Freshwater Aquaculture, Ministry of Agriculture and Rural Affairs
  2. [ZJK202103]

向作者/读者索取更多资源

This study found that GML enhances the resistance of red claw crayfish to WSSV infection by affecting the expression of immune-related genes and modulating immune parameters. GML has a positive impact on the immune system of crayfish, increasing their survival rate and antiviral ability.
Glycerol monolaurate (GML), one of the medium-chain fatty acid esters, is often used as an emulsifier or preservative. Its biological functions include antibacterial and antiviral activities. In this study, we examined the effects of dietary GML on the resistance of the red claw crayfish to WSSV infection. Crayfish fed with 4 g/kg GML showed higher survival rate and lower WSSV copy numbers than the control after WSSV infection. A RT-qPCR analysis showed that GML supplementation enhanced the expression of immune-related genes, especially JAK and caspase. Our data indicate that GML affects the immune parameters of crayfish, including the total hemocyte counts and phenoloxidase, acid phosphatase, superoxide dismutase, lysozyme, and peroxidase activities. After treatment with GML, the apoptosis of hemocytes increased significantly in both WSSV-infected and uninfected crayfish. In summary, GML reduced the mortality of WSSV-infected crayfish, perhaps by modulating the innate immunity of the crayfish. Our study shows that GML can be used to induce the innate immunity and enhance the immune protection of the red claw crayfish against WSSV infection, either therapeutically or as a preventive measure.

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