Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions

Review Genetics & Heredity

Recurrent pregnancy loss: fewer chromosomal abnormalities in products of conception? a meta-analysis

Dan Lei et al.

Summary: The prevalence of chromosomal abnormalities detected in products of conception (POCs) is lower in recurrent pregnancy loss than in sporadic pregnancy loss, and decreases with an increasing number of pregnancy losses.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2022)

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Article Cell Biology

A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence

Hui-Li Yang et al.

Summary: Decidual macrophages (dMφ), important regulators of maternal-fetal immune tolerance and trophoblast invasion during pregnancy, display an active glycerophospholipid metabolism and their adhesion and retention, as well as M2 differentiation, are facilitated by the activation of ENPP2-lysophosphatidic acid (LPA). This process involves the activation of LPA receptors, mediated through the DDIT4-macroautophagy/autophagy axis, leading to upregulation of multiple adhesion factors and poor trophoblast invasion. Supplementation with LPA or autophagy inducer rapamycin improves dMφ autophagy and cell residence, preventing spontaneous abortion.

AUTOPHAGY (2022)

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Article Biochemistry & Molecular Biology

PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells

Atsuya Tsuru et al.

Summary: PGRMC1 is involved in cellular senescence during decidualization through the regulation of FOXO1 expression.

BIOMOLECULES (2022)

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Article Cell Biology

Phenotyping of immune and endometrial epithelial cells in endometrial carcinomas revealed by single-cell RNA sequencing

Yu-e Guo et al.

Summary: This study identified multiple cell types in endometrial carcinoma, including distinct CD8(+) T cell states and different monocyte-macrophage populations, with exhausted CD8(+) T cells and macrophages enriched in tumors. Endometrial epithelial cells were classified into stem-like cells, secretory glandular cells, and ciliated cells. The study provides a detailed single-cell resolution view of endometrial carcinoma, showcasing the characteristics of endometrial epithelial cells and the cellular landscape of the tumor immune microenvironment.

AGING-US (2021)

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Article Cell Biology

Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss

Chuang Guo et al.

Summary: The study revealed significant differences in the distribution of decidual immune cell subsets in patients with recurrent pregnancy loss, as well as a reduced proportion of NK cells supporting embryo growth. Furthermore, alterations in cellular interactions between immune cell subsets within the decidua and those with stromal cells and extravillous trophoblast were observed in the disease state.

CELL DISCOVERY (2021)

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Article Genetics & Heredity

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Luz Garcia-Alonso et al.

Summary: Researchers have analyzed the dynamic changes of the human endometrium using single-cell and spatial transcriptomic profiling, revealing the regulatory role of WNT and NOTCH signaling pathways in differentiation into secretory and ciliated epithelial lineages.

NATURE GENETICS (2021)

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Article Biochemistry & Molecular Biology

Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation

Chow-Seng Kong et al.

Summary: The study found that uterine natural killer cells play a crucial role in embryo biosensing and implantation process, highlighting their importance in selectively eliminating senescent decidual cells.

FASEB JOURNAL (2021)

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Review Medicine, General & Internal

Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss

Siobhan Quenby et al.

Summary: Miscarriage, characterized by the loss of a pregnancy before viability, has a significant global impact with a high occurrence rate and various risk factors. It can result in both physical and psychological consequences for individuals, highlighting the importance of providing mental health support and specialized obstetric care for women who have experienced miscarriage.

LANCET (2021)

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Review Biochemistry & Molecular Biology