4.5 Review

An update on post-transcriptional regulation of retrotransposons

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Review Obstetrics & Gynecology

Control of LINE-1 Expression Maintains Genome Integrity in Germline and Early Embryo Development

Fabiana B. Kohlrausch et al.

Summary: Maintenance of genome integrity is crucial for mammalian development in germline and preimplantation embryos. L1 retrotransposon plays an important role in germline and early embryo development in mice and humans, and its activation and expression are essential for preimplantation development. Although there have been studies on L1 expression at different stages of development, the developmental consequences of this expression remain poorly understood, and further research is needed to elucidate the relationship between L1 retrotransposition events and genomic instability during germline and early embryo development.

REPRODUCTIVE SCIENCES (2022)

Article Multidisciplinary Sciences

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV

Roy Matkovic et al.

Summary: The study reveals the mechanism of how the Human Silencing Hub (HUSH) complex, consisting of TASOR, MPP8, and Periphilin, recruits the histone methyl-transferase SETDB1 to spread repressive marks across genes and transgenes. It is found that TASOR interacts with RNA exosome and RNA Polymerase II, contributing to the repression of HIV expression at both transcriptional and post-transcriptional levels.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

William Garland et al.

Summary: This study describes a functional connection between two complexes involved in nuclear RNA decay and the epigenetic silencing of TEs. The HUSH complex recruits the NEXT complex to TE loci to suppress TE RNA expression. The synergistic action of HUSH and NEXT suppresses the genotoxic potential of TE RNAs.

MOLECULAR CELL (2022)

Article Biochemistry & Molecular Biology

The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition

Lingyun Li et al.

Summary: The YTHDC2 protein plays a crucial role in mammalian fertility by binding to specific sites on the 3' UTRs of mouse testicular RNA targets. The loss of its 3'-> 5' RNA helicase activity leads to infertility in mice. Furthermore, its weak helicase activity is enhanced through interaction with the exoribonuclease XRN1. Studies on ythdc2 mutant zebrafish demonstrate its conserved role in animal germ cell development.

MOLECULAR CELL (2022)

Review Cell Biology

Applications of the versatile CRISPR-Cas13 RNA targeting system

Martyna Kordys et al.

Summary: CRISPR-Cas13 is a highly versatile prokaryotic defense system that has been widely used in killing antibiotic-resistant bacteria, developing highly sensitive detection tools, and regulating gene expression. Additionally, Cas13 can be applied to in vivo RNA modifications and the detection of RNA-interacting proteins among other applications.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2022)

Review Cell Biology

Unwinding the roles of RNA helicase MOV10

Aatiqa Nawaz et al.

Summary: MOV10, an RNA helicase, plays a key role in cellular response to viral infection, suppression of retrotransposition, and development. It associates with various proteins, undergoes posttranslational modifications, and exhibits cell type-specific localization. Studies on MOV10 have primarily focused on germline cells and neurons.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2022)

Article Biochemistry & Molecular Biology

Sequestration of LINE-1 in cytosolic aggregates by MOV10 restricts retrotransposition

Rajika Arora et al.

Summary: This study reveals that alternative mechanisms exist to regulate the activity of L1 retroelements during early stages of mouse embryonic development. L1 ribonucleoprotein complexes and the RNA helicase MOV10 form aggregates in the cytoplasm, preventing L1 retrotransposition. Understanding these mechanisms could lead to potential therapeutic strategies for diseases associated with upregulated L1 activity.

EMBO REPORTS (2022)

Article Biochemistry & Molecular Biology

Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development

Christopher J. Playfoot et al.

Summary: Transposable elements (TEs) play a role in the evolution of gene regulatory networks and are dynamically expressed throughout human brain development. This study investigates the spatiotemporal expression of TE-embedded miRNAs in different stages of human brain development. The results show that TE-embedded miRNAs exhibit spatiotemporal dynamics and have potential functional roles in neurogenesis. The study also reveals distinct expression patterns of TE-embedded miRNAs in the cerebellum compared to other brain regions, suggesting the presence of a previously undetected miRNA control network.
Article Biochemistry & Molecular Biology

Knockouts of TUT7 and 3'hExo show that they cooperate in histone mRNA maintenance and degradation

Chris E. Holmquist et al.

Summary: Metazoan histone mRNAs, which are not polyadenylated and are tightly regulated, undergo degradation and modification with the involvement of 3'hExo and TUT7.
Article Multidisciplinary Sciences

Genome surveillance by HUSH-mediated silencing of intronless mobile elements

Marta Seczynska et al.

Summary: HUSH complex transcriptionally represses L1s and retroviruses through H3K9me3. It recognizes and silences various long, intronless transgenes. HUSH binds and represses endogenous intronless genes, providing immediate protection against new elements.

NATURE (2022)

Article Multidisciplinary Sciences

m6A RNA methylation regulates the fate of endogenous retroviruses

Tomasz Chelmicki et al.

Summary: Research indicates that m(6)A RNA methylation can restrict ERVs, maintaining cellular integrity by reducing the half-life of IAP mRNA to clear reactive ERV-derived RNA species.

NATURE (2021)

Review Virology

Recognize Yourself-Innate Sensing of Non-LTR Retrotransposons

Justine Lagisquet et al.

Summary: Although mobile genetic elements are important in genome evolution, excessive activity can trigger autoimmune reactions, leading to severe autoinflammatory disorders. Cells have protective measures to restrict and sense the enhanced activity of these intragenomic pathogens. Recognizing the immunogenic patterns derived from active elements like LINE-1 and Alu can provide insights into autoimmune diseases.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

Jiadong Liu et al.

Summary: The study reveals that the m(6)A RNA modification and YTHDC1 play essential roles in regulating retrotransposons and cellular reprogramming during early mouse embryonic development.

NATURE (2021)

Article Multidisciplinary Sciences

L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force

Sung-Yeon Hwang et al.

Summary: The study reveals that m(6)A modifications on L1 RNA enhance translation efficiency and retrotransposition in human cells. M(6)A motifs are more enriched in evolutionary young L1s.

NATURE COMMUNICATIONS (2021)

Article Biophysics

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain

Jocelyn C. Newton et al.

Summary: L1 element autonomously replicates in the human genome, causing DNA damage and genomic instability. Activation of L1 triggers interferon response and age-associated inflammation. ORF1 protein forms liquid droplets in a salt-dependent manner, with interactions between its N-terminal and coiled-coil domain being necessary for phase separation.

BIOPHYSICAL JOURNAL (2021)

Article Microbiology

Enterovirus Infection Restricts Long Interspersed Element 1 Retrotransposition

Yan Li et al.

Summary: This study investigated the impact of enteroviral infection on L1 mobility, revealing that different enteroviruses can block L1 transposition. Additionally, viral proteins EV-D68 2A, 3A, 3C, and EV-A71 ORF2p were identified as inhibitors of L1 activity.

FRONTIERS IN MICROBIOLOGY (2021)

Article Oncology

HCV Activates Somatic L1 Retrotransposition-A Potential Hepatocarcinogenesis Pathway

Praveen D. Sudhindar et al.

Summary: Chronic hepatitis C virus infection can activate L1 retrotransposons, potentially contributing to hepatocellular carcinoma development in patients with active or cleared viral infection. The study suggests a novel pathway for liver cancer development in chronic HCV patients.

CANCERS (2021)

Article Microbiology

Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells

Anja Schobel et al.

Summary: HCV infection increases levels of endogenous L1 protein and restricts retrotransposition of engineered L1 reporter elements by inducing stress granules.

PLOS PATHOGENS (2021)

Article Cell Biology

Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos

Chuan Chen et al.

Summary: The study reveals that YTHDC1 plays crucial roles in the self-renewal and differentiation of mouse embryonic stem cells, depending on its m(6)A binding ability. YTHDC1 recognizes m(6)A on LINE1 RNAs in the nucleus, regulating chromatin recruitment and transcriptional activities.

PROTEIN & CELL (2021)

Review Cell Biology

Not So Dead Genes-Retrocopies as Regulators of Their Disease-Related Progenitors and Hosts

Joanna Ciomborowska-Basheer et al.

Summary: Retroposition is an RNA-based gene duplication process that initially creates nonfunctional single exon copies, but many of these copies later gain transcriptional capabilities and function as regulatory long noncoding RNAs. They can regulate other genes through mechanisms such as miRNA sponging, alternative splicing modulation, epigenetic regulation, and competition for stabilizing factors.
Article Cell Biology

RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability

Feng Xiong et al.

Summary: Through the development of a new method MINT-Seq, it was discovered that many classes of RTE RNAs, particularly intronic L1s, are strongly methylated with m(6)A, promoting L1 retrotransposition. This m(6)A-orchestrated L1-host interaction plays widespread roles in gene regulation, genome integrity, human development, and diseases.

CELL RESEARCH (2021)

Editorial Material Cell Biology

Nascent RNA m6A modification at the heart of the gene-retrotransposon conflict

Victor Billon et al.

Summary: Retrotransposons, abundant mobile genetic elements in mammalian genomes, can interfere with genomic processes such as gene transcription. A study shows that segments of nascent RNAs containing retrotransposons are enriched in N-6-methyladenosine and act as transcriptional roadblocks, but cellular proteins SAFB/SAFB2 can alleviate this effect.

CELL RESEARCH (2021)

Article Genetics & Heredity

N-6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

Abdulkadir Abakir et al.

NATURE GENETICS (2020)

Article Genetics & Heredity

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin et al.

NATURE GENETICS (2020)

Article Biochemistry & Molecular Biology

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Daniel Ardeljan et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells

Paolo Mita et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Identification and characterization of occult human-specific LINE-1 insertions using long-read sequencing technology

Weichen Zhou et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Biochemistry & Molecular Biology

A Mechanism for microRNA Arm Switching Regulated by Uridylation

Haedong Kim et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

Dynamic RNA 3′ Uridylation and Guanylation during Mitosis

Yusheng Liu et al.

ISCIENCE (2020)

Article Multidisciplinary Sciences

Human TRIM5α senses and restricts LINE-1 elements

Bianca Volkmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

Christopher H. Douse et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

Pablo Tristan-Ramos et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s

Hale Tunbak et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication

Diane A. Flasch et al.

Review Biochemistry & Molecular Biology

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Hailing Shi et al.

MOLECULAR CELL (2019)

Review Genetics & Heredity

RNases H: Structure and mechanism

Malwina Hyjek et al.

DNA REPAIR (2019)

Article Biochemistry & Molecular Biology

LINE-1 Evasion of Epigenetic Repression in Humans

Francisco J. Sanchez-Luque et al.

MOLECULAR CELL (2019)

Article Biochemical Research Methods

FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control

Ivano Legnini et al.

NATURE METHODS (2019)

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Completion of LINE integration involves an open '4-way' branched DNA intermediate

Brijesh B. Khadgi et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

RNA ligation precedes the retrotransposition of U6/LINE-1 chimeric RNA

John B. Moldovan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

A role for DIS3L2 over natural nonsense-mediated mRNA decay targets in human cells

Paulo J. da Costa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Genetics & Heredity

PIWI-interacting RNAs: small RNAs with big functions

Deniz M. Ozata et al.

NATURE REVIEWS GENETICS (2019)

Article Genetics & Heredity

LINE-1 ORF2p expression is nearly imperceptible in human cancers

Daniel Ardeljan et al.

MOBILE DNA (2019)

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Neurosciences

Overexpression of LINE-1 Retrotransposons in Autism Brain

Svitlana Shpyleva et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

Sadeem Ahmad et al.

Article Biochemistry & Molecular Biology

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity

Michelle Percharde et al.

Article Biochemistry & Molecular Biology

RNase H2, mutated in Aicardi-Goutieres syndrome, promotes LINE-1 retrotransposition

Maria Benitez-Guijarro et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

Luisa Robbez-Masson et al.

GENOME RESEARCH (2018)

Article Cell Biology

A brief history of autophagy from cell biology to physiology and disease

Noboru Mizushima

NATURE CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition

Jongsu Choi et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

HIV-1 Vpr and p21 restrict LINE-1 mobility

Koudai Kawano et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Biochemistry & Molecular Biology

The life of U6 small nuclear RNA, from cradle to grave

Allison L. Didychuk et al.

Article Multidisciplinary Sciences

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Akiko Takahashi et al.

NATURE COMMUNICATIONS (2018)

Review Geriatrics & Gerontology

Ageing: from inflammation to cancer

Giulia C. Leonardi et al.

IMMUNITY & AGEING (2018)

Article Genetics & Heredity

The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation

Alexandra Herrmann et al.

MOBILE DNA (2018)

Article Biochemistry & Molecular Biology

Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing

Jan Attig et al.

Article Biochemistry & Molecular Biology

Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s

Zbigniew Warkocki et al.

Article Biochemistry & Molecular Biology

Terminal uridylyltransferases target RNA viruses as part of the innate immune system

Jeremie Le Pen et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

NMD-degradome sequencing reveals ribosome-bound intermediates with 3′-end non-templated nucleotides

Tatsuaki Kurosaki et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Biology

Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism

Zbigniew Warkocki et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2018)

Review Biotechnology & Applied Microbiology

Ten things you should know about transposable elements

Guillaume Bourque et al.

GENOME BIOLOGY (2018)

Article Genetics & Heredity

The Nucleotide Excision Repair Pathway Limits L1 Retrotransposition

Geraldine Servant et al.

GENETICS (2017)

Article Biochemistry & Molecular Biology

Engineered LINE-1 retrotransposition in nondividing human neurons

Angela Macia et al.

GENOME RESEARCH (2017)

Review Genetics & Heredity

Regulatory activities of transposable elements: from conflicts to benefits

Edward B. Chuong et al.

NATURE REVIEWS GENETICS (2017)

Article Genetics & Heredity

The Nucleotide Excision Repair Pathway Limits L1 Retrotransposition

Geraldine Servant et al.

GENETICS (2017)

Article Evolutionary Biology

Evolution and Diversity of Transposable Elements in Vertebrate Genomes

Cibele G. Sotero-Caio et al.

GENOME BIOLOGY AND EVOLUTION (2017)

Article Biochemistry & Molecular Biology

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

Kareen Bartsch et al.

HUMAN MOLECULAR GENETICS (2017)

Article Biochemistry & Molecular Biology

MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1

Adam Idica et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

Hai Dang Nguyen et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

Arnaud Hubstenberger et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

CG dinucleotide suppression enables antiviral defence targeting non-self RNA

Matthew A. Takata et al.

NATURE (2017)

Article Multidisciplinary Sciences

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

Michael Imbeault et al.

NATURE (2017)

Article Multidisciplinary Sciences

cGAS surveillance of micronuclei links genome instability to innate immunity

Karen J. Mackenzie et al.

NATURE (2017)

Article Multidisciplinary Sciences

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Shane M. Harding et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition

Aleksandr B. Sahakyan et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Review Genetics & Heredity

L1 Mosaicism in Mammals: Extent, Effects, and Evolution

Geoffrey J. Faulkner et al.

TRENDS IN GENETICS (2017)

Review Virology

The Role of Somatic L1 Retrotransposition in Human Cancers

Emma C. Scott et al.

VIRUSES-BASEL (2017)

Article Biochemistry & Molecular Biology

G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition

Aleksandr B. Sahakyan et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Genetics & Heredity

A conserved role for the ESCRT membrane budding complex in LINE retrotransposition

Axel V. Horn et al.

PLOS GENETICS (2017)

Review Oncology

Transposable elements in cancer

Kathleen H. Burns

NATURE REVIEWS CANCER (2017)

Article Biochemistry & Molecular Biology

LTR-Retrotransposon Control by tRNA-Derived Small RNAs

Andrea J. Schorn et al.

Article Biochemistry & Molecular Biology

TUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAs

Dmytro Ustianenko et al.

EMBO JOURNAL (2016)

Article Evolutionary Biology

The Evolution of LINE-1 in Vertebrates

Stephane Boissinot et al.

GENOME BIOLOGY AND EVOLUTION (2016)

Review Cell Biology

Multiple LINEs of retrotransposon silencing mechanisms in the mammalian germline

Fang Yang et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Widespread 3′-end uridylation in eukaryotic RNA viruses

Yayun Huo et al.

SCIENTIFIC REPORTS (2016)

Article Cell Biology

Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs

Mehdi Pirouz et al.

CELL REPORTS (2016)

Review Genetics & Heredity

Restricting retrotransposons: a review

John L. Goodier

MOBILE DNA (2016)

Review Genetics & Heredity

Roles for retrotransposon insertions in human disease

Dustin C. Hancks et al.

MOBILE DNA (2016)

Review Cell Biology

Post-Transcriptional Control of LINE-1 Retrotransposition by Cellular Host Factors in Somatic Cells

Javier G. Pizarro et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Ubiquitous L1 Mosaicism in Hippocampal Neurons

Kyle R. Upton et al.

Article Biochemistry & Molecular Biology

5′ UTR m6A Promotes Cap-Independent Translation

Kate D. Meyer et al.

Article Biochemistry & Molecular Biology

Epigenetics of Aging

Marta I. Sierra et al.

CURRENT GENOMICS (2015)

Article Biochemistry & Molecular Biology

U6 snRNA Pseudogenes: Markers of Retrotransposition Dynamics in Mammals

Aurelien J. Doucet et al.

MOLECULAR BIOLOGY AND EVOLUTION (2015)

Article Biochemistry & Molecular Biology

A 3′ Poly(A) Tract Is Required for LINE-1 Retrotransposition

Aurelien J. Doucet et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

An integrated map of structural variation in 2,504 human genomes

Peter H. Sudmant et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

miR-128 represses L1 retrotransposition by binding directly to L1 RNA

Matthias Hamdorf et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Multidisciplinary Sciences

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

Iva A. Tchasovnikarova et al.

SCIENCE (2015)

Article Biochemistry & Molecular Biology

miR-128 represses L1 retrotransposition by binding directly to L1 RNA

Matthias Hamdorf et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Genetics & Heredity

The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

John B. Moldovan et al.

PLOS GENETICS (2015)

Article Genetics & Heredity

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

John L. Goodier et al.

PLOS GENETICS (2015)

Article Microbiology

The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes

Sandra R. Richardson et al.

MICROBIOLOGY SPECTRUM (2015)

Article Biochemistry & Molecular Biology

Uridylation by TUT4 and TUT7 Marks mRNA for Degradation

Jaechul Lim et al.

Article Biochemistry & Molecular Biology

Functional microRNAs and target sites are created by lineage-specific transposition

Ryan M. Spengler et al.

HUMAN MOLECULAR GENETICS (2014)

Article Multidisciplinary Sciences

Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway

Christopher R. Faehnle et al.

NATURE (2014)

Article Multidisciplinary Sciences

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

Frank M. J. Jacobs et al.

NATURE (2014)

Review Immunology

The enemy within: endogenous retroelements and autoimmune disease

Hannah E. Volkman et al.

NATURE IMMUNOLOGY (2014)

Article Biochemistry & Molecular Biology

RNase L restricts the mobility of engineered retrotransposons in cultured human cells

Ao Zhang et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Virology

Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility

Tommy E. White et al.

VIROLOGY (2014)

Article Multidisciplinary Sciences

Autophagy supports genomic stability by degrading retrotransposon RNA

Huishan Guo et al.

NATURE COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

XRN 5′ → 3′ exoribonucleases: Structure, mechanisms and functions

Vinay K. Nagarajan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2013)

Article Biochemistry & Molecular Biology

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

J. Ross Buchan et al.

Article Biochemistry & Molecular Biology

The MOV10 Helicase Inhibits LINE-1 Mobility

Xiaoyu Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

The zebrafish reference genome sequence and its relationship to the human genome

Kerstin Howe et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

The Microprocessor controls the activity of mammalian retrotransposons

Sara R. Heras et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition

John L. Goodier et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Biochemistry & Molecular Biology

Extensive somatic L1 retrotransposition in colorectal tumors

Szilvia Solyom et al.

GENOME RESEARCH (2012)

Article Biochemistry & Molecular Biology

Poly(A) Binding Protein C1 Is Essential for Efficient L1 Retrotransposition and Affects L1 RNP Formation

Lixin Dai et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

RNase H2-Initiated Ribonucleotide Excision Repair

Justin L. Sparks et al.

MOLECULAR CELL (2012)

Article Multidisciplinary Sciences

Embryonic stem cell potency fluctuates with endogenous retrovirus activity

Todd S. Macfarlan et al.

NATURE (2012)

Article Multidisciplinary Sciences

A unique regulatory phase of DNA methylation in the early mammalian embryo

Zachary D. Smith et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

The non-autonomous retrotransposon SVA is trans-mobilized by the human LINE-1 protein machinery

Julija Raiz et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

LINE-1 Retroelements Complexed and Inhibited by Activation Induced Cytidine Deaminase

Mirjam Metzner et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes

You-Qiang Su et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

MARF1 Regulates Essential Oogenic Processes in Mice

You-Qiang Su et al.

SCIENCE (2012)

Article Genetics & Heredity

MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells

John L. Goodier et al.

PLOS GENETICS (2012)

Article Biochemistry & Molecular Biology

Retrotransposition of marked SVA elements by human L1s in cultured cells

Dustin C. Hancks et al.

HUMAN MOLECULAR GENETICS (2011)

Article Biochemistry & Molecular Biology

Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

Michal Lubas et al.

MOLECULAR CELL (2011)

Article Multidisciplinary Sciences

Somatic retrotransposition alters the genetic landscape of the human brain

J. Kenneth Baillie et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition

Elena Khazina et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells

Nicole G. Coufal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation

Marie-Joelle Schmidt et al.

Article Multidisciplinary Sciences

HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex

Johannes Popow et al.

SCIENCE (2011)

Article Biochemistry & Molecular Biology

LINE-1 Retrotransposition Activity in Human Genomes

Christine R. Beck et al.

Article Biochemistry & Molecular Biology

Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion

John L. Goodier et al.

HUMAN MOLECULAR GENETICS (2010)

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