期刊
FEBS JOURNAL
卷 290, 期 8, 页码 2011-2021出版社
WILEY
DOI: 10.1111/febs.16698
关键词
10-23 DNAzyme; DNAzymes; MD; NMR
Understanding the molecular features of catalytically active DNA sequences, known as DNAzymes, is crucial for comprehending their fundamental properties and unleashing their full potential through tailored modifications. Our recent research on the 10-23 DNAzyme has provided valuable insights into its unique molecular architecture, conformational plasticity, and dynamic modulation by metal ions, contributing to the exploration of DNA-mediated catalysis.
Understanding the molecular features of catalytically active DNA sequences, so-called DNAzymes, is essential not only for our understanding of the fundamental properties of catalytic nucleic acids in general, but may well be the key to unravelling their full potential via tailored modifications. Our recent findings contributed to the endeavour to assemble a mechanistic picture of DNA-mediated catalysis by providing high-resolution structural insights into the 10-23 DNAzyme (Dz) and exposing a complex interplay between the Dz's unique molecular architecture, conformational plasticity, and dynamic modulation by metal ions as central elements of the DNA catalyst. Here, we discuss key features of our findings and compare them to other studies on similar systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据