4.4 Review

Modern vaccine strategies for emerging zoonotic viruses

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Review Food Science & Technology

COVID-19 pandemic sheds light on the importance of food safety practices: risks, global recommendations, and perspectives

Carollyne Maragoni-Santos et al.

Summary: The article discusses food safety during the COVID-19 period, mentioning the unconfirmed transmission of the virus through food, emphasizing the strengthening of food safety and hygiene measures, and looking ahead to innovative food serving methods in the post-pandemic scenario.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Review Virology

mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases

Ting Le et al.

Summary: mRNA vaccines have promising potential in the prevention and treatment of infectious diseases due to their advantages of low risk of insertional mutagenesis, high potency, accelerated development cycles, and potential for low-cost manufacture. Clinical trials of mRNA vaccines for diseases such as rabies, Zika, and influenza have shown promise. The successful application of mRNA vaccines against COVID-19 further validates the platform and highlights its potential in the veterinary field. This review provides an overview of mRNA vaccines and their development technologies, as well as discusses the future directions and challenges of utilizing this promising vaccine platform in veterinary medicine.

VIRUSES-BASEL (2022)

Review Biotechnology & Applied Microbiology

A comprehensive review of SARS-CoV-2 vaccines: Pfizer, Moderna & Johnson & Johnson

Rikin Patel et al.

Summary: This article discusses the mechanisms, side effects, and efficacy of COVID-19 vaccines developed by Pfizer, Moderna, and Johnson & Johnson. The vaccines have been shown to be safe and effective in protecting against moderate and symptomatic SARS-CoV-2 infection. It is important to continuously update the literature on these vaccines, especially as they are tested in different age groups and against emerging variants of the SARS-CoV-2 coronavirus.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2022)

Article Multidisciplinary Sciences

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

Kathrin Leppek et al.

Summary: The authors developed a platform called PERSIST-seq for studying mRNA stability, ribosome load, and solution stability to improve mRNA therapeutics. They found that in-cell stability is a greater driver of protein output than ribosome load and introduced a method called In-line-seq for mitigating hydrolytic degradation. Their findings demonstrate the simultaneous improvement of mRNA stability and protein expression.

NATURE COMMUNICATIONS (2022)

Article Multidisciplinary Sciences

A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

Junyu Chen et al.

Summary: Significant progress has been made in the development of intramuscular vaccines against SARS-CoV-2, but they have limitations in eliciting local immunity in the respiratory tract. To overcome this, researchers have constructed a nasal vaccine candidate using an influenza vector that contains the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Preclinical studies have shown that this vaccine candidate provides protection against lung pathology and demonstrates cross-protection against SARS-CoV-2 variants and other influenza viruses.

SCIENCE BULLETIN (2022)

Review Biochemistry & Molecular Biology

Self-amplifying RNA vaccines for infectious diseases

Kristie Bloom et al.

Summary: Vaccinology is moving towards synthetic RNA platforms, which offer rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. Self-amplifying RNAs have shown enhanced antigen expression at lower doses compared to conventional mRNA, potentially improving immunity and becoming important vaccine candidates.

GENE THERAPY (2021)

Article Biology

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

Manuel J. Carrasco et al.

Summary: The study reports a method that can predict the pKa of lipid nanoparticles (LNPs) from the structure of the ionizable lipid, and investigates the delivery efficiency and factors influencing LNPs both in vitro and in vivo. It was also found that LNPs with more negative charge lead to higher off-target systemic mRNA expression.

COMMUNICATIONS BIOLOGY (2021)

Article Health Policy & Services

Addressing vaccine hesitancy and access barriers to achieve persistent progress in Israel's COVID-19 vaccination program

Bruce Rosen et al.

Summary: Israel achieved high vaccination coverage and overcame barriers to vaccine uptake through a combination of efforts targeting the general population and specific subgroups. The country's vaccination campaign faced challenges such as hesitancy, access issues, and confusion about vaccine effectiveness, which were addressed through messaging, incentives, and adaptations to the delivery system. The strategies used by Israel to improve vaccine uptake may be relevant to other countries facing similar challenges in vaccination campaigns.

ISRAEL JOURNAL OF HEALTH POLICY RESEARCH (2021)

Review Plant Sciences

Plant molecular farming for the production of valuable proteins ? Critical evaluation of achievements and future challenges

Stefan Schillberg et al.

Summary: This article discusses the importance of recombinant proteins in various fields such as food, chemical, and pharmaceutical industries, as well as the development of molecular farming as a production platform. With molecular farming products gradually entering the market, but limited by various factors, success stories remain relatively few.

JOURNAL OF PLANT PHYSIOLOGY (2021)

Editorial Material Biotechnology & Applied Microbiology

RNA-based vaccines and innate immune activation: Not too hot and not too cold

Robert Frederickson et al.

MOLECULAR THERAPY (2021)

Letter Medicine, General & Internal

Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine

Kai Wu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Biotechnology & Applied Microbiology

Developing a Nicotiana benthamiana transgenic platform for high-value diterpene production and candidate gene evaluation

Edith C. F. Forestier et al.

Summary: The research aimed to engineer Nicotiana benthamiana to produce novel diterpenoids by up-regulating key genes to increase the precursor GGPP production. Optimal combinations of MEP pathway genes led to a significant increase in casbene production, showcasing the importance of stable transformants for gene discovery in the production of complex diterpenoids.

PLANT BIOTECHNOLOGY JOURNAL (2021)

Article Medicine, General & Internal

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

Eric J. Haas et al.

Summary: This study assessed the real-world effectiveness of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 in Israel, showing high efficacy in preventing SARS-CoV-2 infections, hospitalizations, severe disease, and death. As vaccine coverage increased, there were marked declines in SARS-CoV-2 outcomes, indicating that COVID-19 vaccination can help control the pandemic.

LANCET (2021)

Review Pharmacology & Pharmacy

Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management

Vivek P. Chavda et al.

Summary: Intranasal vaccines have advantages in targeting SARS-CoV-2 infection, eliciting immune responses, and avoiding infections, while also convenient for self-administration and storage at ambient temperatures.

DRUG DISCOVERY TODAY (2021)

Article Biochemistry & Molecular Biology

New Computational Approach for Peptide Vaccine Design Against SARS-COV-2

Subhamoy Biswas et al.

Summary: The study established a precise computational method using new mathematical parameters to identify conserved and surface-exposed regions on virus surface proteins for potential peptide vaccine candidates. This method successfully identified vaccine targets against SARS-CoV-2 and showed promise for extending to other viruses like Zika and Hendra.

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2021)

Review Biotechnology & Applied Microbiology

Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

Aravind Madhavan et al.

Summary: Manufacture of recombinant therapeutics is a rapidly growing field in pharmaceuticals, with yeasts being established as important hosts for producing heterologous proteins. Advances in yeast gene manipulation tools and techniques have enabled customization of yeast cells for therapeutic protein synthesis, utilizing strategies such as secretory pathway engineering and glycosylation engineering.

MICROBIAL CELL FACTORIES (2021)

Review Biotechnology & Applied Microbiology

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Namit Chaudhary et al.

Summary: mRNA vaccines have been established as a rapid, effective, and safe approach for protecting individuals from infectious diseases, especially during the COVID-19 pandemic. Further research is needed to optimize mRNA vaccine design, delivery, and applications for a range of infectious diseases.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Genetics & Heredity

CRISPR-Based Genome Editing Tools: Insights into Technological Breakthroughs and Future Challenges

Muntazir Mushtaq et al.

Summary: Genome-editing technology, particularly the transgene-free approach, has great potential in achieving global food security. Recent developments in CRISPR-based tools for crop improvement include the development of transgene-free genome plants, compatible nucleases, and safe delivery vehicles. Despite the promising advancements, challenges remain in efficient delivery of CRISPR reagents, precision genome editing, and navigating government policies and public acceptance.
Review Immunology

Current updates and research on plant-based vaccines for coronavirus disease 2019

Asqwin Uthaya Kumar et al.

Summary: COVID-19 has become a global pandemic, causing over a million deaths. Plant-based vaccines are gaining attention for their cost-effectiveness and efficient manufacturing process. Many companies worldwide are racing to develop an effective vaccine using the plant system amid challenges faced in the development process.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2021)

Article Surgery

Endoscopic retrieval of an accidentally ingested bur during a dental procedure: a case report

Keerthana Kunaparaju et al.

Summary: This case report emphasizes the importance of using physical barriers during dental procedures to prevent medical emergencies. Dentists need to undergo emergency medical training to handle unforeseen situations, and each incident encountered should be thoroughly documented for guidance.

PATIENT SAFETY IN SURGERY (2021)

Article Biotechnology & Applied Microbiology

A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity

Tim Beissert et al.

MOLECULAR THERAPY (2020)

Review Biochemistry & Molecular Biology

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

Sergio Linares-Fernandez et al.

TRENDS IN MOLECULAR MEDICINE (2020)

Review Microbiology

Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses

Ning Wang et al.

FRONTIERS IN MICROBIOLOGY (2020)

Review Immunology

DNA vaccines: prime time is now

Ebony N. Gary et al.

CURRENT OPINION IN IMMUNOLOGY (2020)

Review Nanoscience & Nanotechnology

Immune-mediated approaches against COVID-19

Helena F. Florindo et al.

NATURE NANOTECHNOLOGY (2020)

Editorial Material Medicine, General & Internal

Amplifying RNA Vaccine Development

Deborah H. Fuller et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Immunology

Emerging viruses and current strategies for vaccine intervention

B. Afrough et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo

Brittany A. Elliott et al.

NATURE COMMUNICATIONS (2019)

Article Genetics & Heredity

Viral quasispecies

Esteban Domingo et al.

PLOS GENETICS (2019)

Editorial Material Cell Biology

The short tail that wags the mRNA

Eytan Zlotorynski

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Biotechnology & Applied Microbiology

Vaccinia-based vaccines to biothreat and emerging viruses

Les P. Nagata et al.

BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 34, ISSUE 1 (2018)

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Engineering, Biomedical

Engineering DNA vaccines against infectious diseases

Jihui Lee et al.

ACTA BIOMATERIALIA (2018)

Article Multidisciplinary Sciences

Host and viral traits predict zoonotic spillover from mammals

Kevin J. Olival et al.

NATURE (2017)

Article Biochemical Research Methods

Production of virus-like particles for vaccines

J. Fuenmayor et al.

NEW BIOTECHNOLOGY (2017)

Review Biochemistry & Molecular Biology

Type I lnterferons Modulate CD8+ T Cell Immunity to mRNA Vaccines

Ans De Beuckelaer et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Review Pharmacology & Pharmacy

Clinical potential of electroporation for gene therapy and DNA vaccine delivery

Laure Lambricht et al.

EXPERT OPINION ON DRUG DELIVERY (2016)

Review Biotechnology & Applied Microbiology

The case for plant-made veterinary immunotherapeutics

Edward Topp et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Medicine, Research & Experimental

Micro- and nanoparticulates for DNA vaccine delivery

Eric Farris et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Article Biotechnology & Applied Microbiology

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

Ans De Beuckelaer et al.

MOLECULAR THERAPY (2016)

Review Chemistry, Multidisciplinary

Peptide-based synthetic vaccines

Mariusz Skwarczynski et al.

CHEMICAL SCIENCE (2016)

Review Biotechnology & Applied Microbiology

Plant-made oral vaccines against human infectious diseases-Are we there yet?

Hui-Ting Chan et al.

PLANT BIOTECHNOLOGY JOURNAL (2015)

Review Immunology

The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review

Andreas Kronbichler et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

Review Immunology

Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants

Marie-Eve Lebel et al.

VACCINES (2015)

Review Biotechnology & Applied Microbiology

Pre-existing immunity against Ad vectors Humoral, cellular, and innate response, what's important?

Hugues Fausther-Bovendo et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

Review Biotechnology & Applied Microbiology

Recent advances and safety issues of transgenic plant-derived vaccines

Zheng-jun Guan et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

Charlotte Pollard et al.

MOLECULAR THERAPY (2013)

Review Biochemical Research Methods

Use of baculovirus expression system for generation of virus-like particles: Successes and challenges

Fuxiao Liu et al.

PROTEIN EXPRESSION AND PURIFICATION (2013)

Article Biodiversity Conservation

A One Health Framework for Estimating the Economic Costs of Zoonotic Diseases on Society

Clare Narrod et al.

ECOHEALTH (2012)

Article Chemistry, Multidisciplinary

Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine

Anna Bershteyn et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Cell Biology

Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway

Stephanie J. Win et al.

IMMUNOLOGY AND CELL BIOLOGY (2011)

Review Biology

How to make predictions about future infectious disease risks

Mark Woolhouse

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)

Article Immunology

Virus-Like Particles as Particulate Vaccines

Luigi Buonaguro et al.

CURRENT HIV RESEARCH (2010)

Article Pharmacology & Pharmacy

Epitope Discovery and Their Use in Peptide Based Vaccines

Nadine L. Dudek et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

Review Immunology

Virus-like particles in vaccine development

Antonio Roldao et al.

EXPERT REVIEW OF VACCINES (2010)

Review Immunology

Vaccines: the Fourth Century

Stanley A. Plotkin

CLINICAL AND VACCINE IMMUNOLOGY (2009)

Article Immunology

Yellow fever and Max Theiler: the only Nobel Prize for a virus vaccine

Erling Norrby

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Review Parasitology

Second-generation vaccines against leishmaniasis

RN Coler et al.

TRENDS IN PARASITOLOGY (2005)

Review Biochemistry & Molecular Biology

T cell vaccines for microbial infections

HL Robinson et al.

NATURE MEDICINE (2005)