4.1 Review

Optimizing levodopa therapy, when and how? Perspectives on the importance of delivery and the potential for an early combination approach

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Effects of One-Day Application of Levodopa/Carbidopa/Entacapone versus Levodopa/Carbidopa/Opicapone in Parkinson's Disease Patients

Thomas Mueller et al.

Summary: The catechol-O-methyltransferase inhibitors entacapone and opicapone prolong the efficacy of conventional oral levodopa/dopa decarboxylase inhibitor formulations through an increase in levodopa plasma bioavailability. The study compared the impact of single-day entacapone or opicapone intake on the pharmacokinetic plasma behavior of levodopa, 3-O-methyldopa, and total homocysteine in Parkinson's disease patients. It was found that opicapone had higher levodopa bioavailability and better baseline scores compared to entacapone.
Article Clinical Neurology

Pharmacokinetics of Intravenously (DIZ101), Subcutaneously (DIZ102), and Intestinally (LCIG) Infused Levodopa in Advanced Parkinson Disease

Filip Bergquist et al.

Summary: This study compared the plasma concentrations of levodopa/carbidopa gel infusion given through subcutaneous or intravenous infusion to oral treatment in patients with advanced Parkinson disease. Results showed that subcutaneous administration achieved therapeutic levodopa concentrations quickly and stably, with good safety and tolerability outcomes.

NEUROLOGY (2022)

Article Clinical Neurology

Effect of Opicapone on Levodopa Pharmacokinetics in Patients with Fluctuating Parkinson's Disease

Joaquim J. Ferreira et al.

Summary: This study evaluated the effects of opicapone on levodopa plasma pharmacokinetics and motor response. The results showed that opicapone can increase the bioavailability of levodopa, decrease off time, and increase on time.

MOVEMENT DISORDERS (2022)

Article Clinical Neurology

Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary A Report of the AAN Guideline Subcommittee

Tamara Pringsheim et al.

Summary: The review found that initial treatment with levodopa provides better motor benefits compared to dopamine agonists, but is also more likely to cause motor complications. There was little evidence to suggest that any particular formulation or method of administration of dopamine agonists is superior. Long-acting forms of levodopa and combination formulations with entacapone do not appear to differ in efficacy from immediate-release levodopa for early disease motor symptoms. Patients using dopamine agonists may have a higher risk of impulse control disorders compared to those using levodopa.

NEUROLOGY (2021)

Article Clinical Neurology

ND0612 (levodopa/carbidopa for subcutaneous infusion) in patients with Parkinson's disease and motor response fluctuations: A randomized, placebo-controlled phase 2 study

Nir Giladi et al.

Summary: ND0612, a continuous subcutaneous levodopa/carbidopa delivery system, was well-tolerated and resulted in reduced OFF time and decreased plasma levodopa fluctuations when used adjunctively in PD patients. Although most patients experienced infusion site nodules, they all resolved without sequelae.

PARKINSONISM & RELATED DISORDERS (2021)

Article Health Care Sciences & Services

Initial Experience of the Levodopa-Entacapone-Carbidopa Intestinal Gel in Clinical Practice

Mezin Othman et al.

Summary: Patients in fluctuating stages of Parkinson's disease benefit from device-aided treatments such as continuous infusion of levodopa-carbidopa intestinal gel (LCIG). This study reports the first clinical experience of levodopa-entacapone-carbidopa intestinal gel (LECIG) therapy, showing potential for use in PD patients. Despite overall satisfaction with the size and usability of the pump, some patients experienced side effects and improvements in software technology are needed.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Review Clinical Neurology

Redefining the strategy for the use of COMT inhibitors in Parkinson's disease: the role of opicapone

Peter Jenner et al.

Summary: Introduction highlights the importance of COMT inhibition in optimizing levodopa delivery to the brain and the potential of opicapone in improving treatment outcomes in early PD.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2021)

Article Clinical Neurology

Subcutaneous Levodopa Infusion for Parkinson's Disease: 1-Year Data from the Open-Label BeyoND Study

Werner Poewe et al.

Summary: The study evaluated the long-term safety of two dosing regimens of ND0612, showing that continuous subcutaneous infusion of levodopa/carbidopa with ND0612 is generally safe, with infusion site reactions being the main adverse event. 56% of patients completed 12 months of treatment, with a reduced discontinuation rate after protocol revision.

MOVEMENT DISORDERS (2021)

Article Clinical Neurology

Levodopa-Carbidopa Intestinal Gel Reduces Dyskinesia in Parkinson's Disease in a Randomized Trial

Eric Freire-Alvarez et al.

Summary: The study showed that LCIG significantly reduced dyskinesia compared to oral optimized medical treatment, and also demonstrated significant improvements in quality of life and activities of daily living in patients with advanced Parkinson's disease.

MOVEMENT DISORDERS (2021)

Article Health Care Sciences & Services

Personalized Medicine Approach in Treating Parkinson's Disease, Using Oral Administration of Levodopa/Carbidopa Microtablets in Clinical Practice

Helga Maria Gretarsdottir et al.

Summary: The study evaluated the individual experience of LC-5 in clinical practice, showing that the majority of patients reported symptom improvement with favorable usability. The results suggest that LC-5 therapy is generally well-tolerated and may offer a personalized approach for fine-tuned PD treatment.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Clinical Neurology

Dyskinesia Matters: But Not as Much as It Used to

K. Ray Chaudhuri et al.

MOVEMENT DISORDERS (2020)

Article Medicine, General & Internal

Randomized Delayed-Start Trial of Levodopa in Parkinson's Disease

C. V. M. Verschuur et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Clinical Neurology

Pharmacokinetics and efficacy of a novel formulation of carbidopa-levodopa (Accordion Pill®) in Parkinson's disease

Peter A. LeWitt et al.

PARKINSONISM & RELATED DISORDERS (2019)

Review Clinical Neurology

Pharmacodynamics, Efficacy, and Safety of IPX203 in Parkinson Disease Patients With Motor Fluctuations

Nishit B. Modi et al.

CLINICAL NEUROPHARMACOLOGY (2019)

Article Clinical Neurology

ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson's disease

Angelo Antonini et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)

Article Clinical Neurology

Impulse Control Disorders in Advanced Parkinson's Disease With Dyskinesia: The ALTHEA Study

Roberta Biundo et al.

MOVEMENT DISORDERS (2017)

Article Clinical Neurology

Personalized Medicine in Parkinson's Disease: Time to Be Precise

Nataliya Titova et al.

MOVEMENT DISORDERS (2017)

Article Medicine, General & Internal

Parkinson disease

Werner Poewe et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Clinical Neurology

Comparison of Selegiline and Rasagiline Therapies in Parkinson Disease: A Real-life Study

Chava Peretz et al.

CLINICAL NEUROPHARMACOLOGY (2016)

Review Pharmacology & Pharmacy

Catechol-O-Methyltransferase Inhibitors in Parkinson's Disease

Thomas Mueller

Article Pharmacology & Pharmacy

Trends in inpatient antiparkinson drug use in the USA, 2001-2012

James A. G. Crispo et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Review Clinical Neurology

MDS clinical diagnostic criteria for Parkinson's disease

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2015)

Review Clinical Neurology

MDS research criteria for prodromal Parkinson's disease

Daniela Berg et al.

MOVEMENT DISORDERS (2015)

Article Clinical Neurology

Gastroretentive Carbidopa/Levodopa, DM-1992, for the Treatment of Advanced Parkinson's Disease

Leo Verhagen Metman et al.

MOVEMENT DISORDERS (2015)

Review Clinical Neurology

Novel Formulations and Modes of Delivery of Levodopa

Werner Poewe et al.

MOVEMENT DISORDERS (2015)

Review Clinical Neurology

Clinical Spectrum of Impulse Control Disorders in Parkinson's Disease

Daniel Weintraub et al.

MOVEMENT DISORDERS (2015)

Review Clinical Neurology

Levodopa Therapy for Parkinson's Disease: Pharmacokinetics and Pharmacodynamics

Peter A. LeWitt

MOVEMENT DISORDERS (2015)

Article Clinical Neurology

Double-Blind Study of the Actively Transported Levodopa Prodrug XP21279 in Parkinson's Disease

Peter A. LeWitt et al.

MOVEMENT DISORDERS (2014)

Article Clinical Neurology

Comparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients

Fabrizio Stocchi et al.

PARKINSONISM & RELATED DISORDERS (2014)

Article Clinical Neurology

The current and projected economic burden of Parkinson's disease in the United States

Stacey L. Kowal et al.

MOVEMENT DISORDERS (2013)

Article Pharmacology & Pharmacy

The effect of different dosing regimens of levodopa/carbidopa/entacapone on plasma levodopa concentrations

Kimmo Ingman et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2012)

Article Clinical Neurology

Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial

D. Nyholm et al.

EUROPEAN JOURNAL OF NEUROLOGY (2012)

Review Clinical Neurology

The long-duration response to levodopa: Phenomenology, potential mechanisms and clinical implications

Elise Anderson et al.

PARKINSONISM & RELATED DISORDERS (2011)

Review Clinical Neurology

When Do Levodopa Motor Fluctuations First Appear in Parkinson's Disease?

Fabrizio Stocchi et al.

EUROPEAN NEUROLOGY (2010)

Review Clinical Neurology

A reassessment of risks and benefits of dopamine agonists in Parkinson's disease

Angelo Antonini et al.

LANCET NEUROLOGY (2009)

Article Clinical Neurology

Adherence to Antiparkinson Medication in a Multicenter European Study

Donald Grosset et al.

MOVEMENT DISORDERS (2009)

Review Medicine, General & Internal

Monoamine oxidase B inhibitors versus other dopaminergic agents in early Parkinson's disease

Robert Caslake et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2009)

Editorial Material Pharmacology & Pharmacy

An expert opinion on safinamide in Parkinson's disease

Marco Onofrj et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2008)

Article Clinical Neurology

The progression of Parkinson disease - A hypothesis

Anthony E. Lang

NEUROLOGY (2007)

Review Clinical Neurology

Relating mode of action to clinical practice: Dopaminergic agents in Parkinson's disease

Peter Riederer et al.

PARKINSONISM & RELATED DISORDERS (2007)

Article Clinical Neurology

Factors associated with the development of motor fluctuations and dyskinesias in Parkinson disease

Robert A. Hauser et al.

ARCHIVES OF NEUROLOGY (2006)

Article Clinical Neurology

Timing of treatment initiation in Parkinson's disease: A need for reappraisal?

AHV Schapira et al.

ANNALS OF NEUROLOGY (2006)

Article Clinical Neurology

Treatment should not be initiated too soon in Parkinson's disease

MJ Aminoff

ANNALS OF NEUROLOGY (2006)

Article Clinical Neurology

Suboptimal medication adherence in Parkinson's disease

KA Grosset et al.

MOVEMENT DISORDERS (2005)

Review Clinical Neurology

Levodopa in the treatment of Parkinson's disease: Current controversies

CW Olanow et al.

MOVEMENT DISORDERS (2004)

Article Pharmacology & Pharmacy

Entacapone increases and prolongs the central effects of L-DOPA in the 6-hydroxydopamine-lesioned rat

M Gerlach et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2004)

Article Medicine, General & Internal

Pramipexole vs levodopa as initial treatment for Parkinson disease - A randomized controlled trial

R Holloway et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)