☆ 4.6 Review

Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy

EXPERT OPINION ON DRUG DELIVERY (2023)

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Article Engineering, Biomedical

Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery

Jianhua He et al.

Summary: Nanoparticle-based therapeutics show potential for treating atherosclerosis, but the complex plaque microenvironment hinders their targeting ability. In this study, we developed reactive oxygen species (ROS)-responsive and size-reducible nanoassemblies to overcome this barrier. These nanoassemblies specifically accumulated in atherosclerotic plaque, rapidly disassembled in response to excess ROS, and released smaller nanoparticles for deeper penetration and targeted drug delivery. In vivo studies demonstrated that the nanoassemblies reduced plaque size, lipid deposition, macrophage content, and local inflammatory factor levels, while also alleviating systemic inflammation. Overall, the ROS-responsive and size-reducible nanoassemblies exhibit enhanced targeting ability and provide an effective approach for atherosclerosis therapy.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Precision biomaterials in cancer theranostics and modelling

David Caballero et al.

Summary: Traditional cancer treatment approaches are becoming obsolete, leading to more patients failing to respond to treatments. Personalized genetic profiling offers a more accurate method of treatment, but still faces issues like low local drug efficacy. Efforts are now focused on developing precision medicine-based strategies to improve cancer treatment efficiency.

BIOMATERIALS (2022)

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Review Immunology

Neoantigen-based personalized cancer vaccines: the emergence of precision cancer immunotherapy

Guilhem Richard et al.

Summary: The field of cancer therapy has been transformed in less than a decade with the introduction of checkpoint inhibitors, next generation sequencing, and the discovery of neoantigens. Immune responses to neoantigens through vaccination have become a focus in precision immunotherapy. Validation of personalized vaccine design pipelines is crucial for revolutionizing neoantigen-based vaccine design and delivery.

EXPERT REVIEW OF VACCINES (2022)

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Article Chemistry, Multidisciplinary

Neoantigen Immunotherapeutic-Gel Combined with TIM-3 Blockade Effectively Restrains Orthotopic Hepatocellular Carcinoma Progression

Qingfu Zhao et al.

Summary: This study combines various therapeutic approaches, such as liver cancer-specific neoantigen, immune agonists, and TIM-3 blockade, using a silk-hydrogel package to effectively treat and provide long-term immune protection against orthotopic hepatocellular carcinoma (HCC). The synergistic immunotherapy significantly reduces tumor growth, prevents metastasis, and establishes long-term memory against tumor rechallenge.

NANO LETTERS (2022)

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Article Biotechnology & Applied Microbiology

Inhibition of post-surgery tumour recurrence via a sprayable chemo-immunotherapy gel releasing PD-L1 antibody and platelet-derived small EVs

Jian Zhao et al.

Summary: In this study, a bioresponsive gel combined with chemoimmunotherapeutic agents was developed to effectively inhibit both local tumor recurrence and metastasis. The gel promoted tumor immunogenic cell death and induced a strong antitumor immune response. The concurrent release of an anti-PD-L1 antibody impaired the PD-1/PD-L1 pathway and improved the tumor-killing effect of cytotoxic T cells.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Oncology

Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinoma

Mona O. Mohsen et al.

Summary: This study developed a multitarget vaccine using long neoantigenic peptides and virus-like particles as an efficient vaccine platform. The vaccination with long peptides showed superior anti-tumor effects and decreased tumor recurrence and metastases, despite the low mutational burden of the tumor.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Chemistry, Multidisciplinary

Two-Pronged Intracellular Co-Delivery of Antigen and Adjuvant for Synergistic Cancer Immunotherapy

Junli Meng et al.

Summary: Nanovaccines that can co-deliver antigen and adjuvant to dendritic cells have emerged as effective tools for activating antitumor immune responses, inhibiting tumor growth, and improving survival rates.

ADVANCED MATERIALS (2022)

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Article Immunology

Bioinspired vaccines to enhance MHC class-I antigen cross-presentation

Jessalyn J Baljon et al.

CURRENT OPINION IN IMMUNOLOGY (2022)

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Article Oncology

Neoantigen Identification and Response to Adoptive Cell Transfer in Anti-PD-1 Naive and Experienced Patients with Metastatic Melanoma

Shoshana T. Levi et al.

Summary: The study found that anti-PD-1 naive patients had higher tumor mutational burdens and reacted to more neoantigens compared to anti-PD-1 experienced patients. These findings partially explain the difference in response rates between the two groups.

CLINICAL CANCER RESEARCH (2022)

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Article Immunology

Intranodal Administration of Neoantigen Peptide-loaded Dendritic Cell Vaccine Elicits Epitope-specific T Cell Responses and Clinical Effects in a Patient with Chemorefractory Ovarian Cancer with Malignant Ascites

Takashi Morisaki et al.

Summary: The study demonstrates the clinical and immunological effects of neoantigen peptide-loaded DC-based immunotherapy in a patient with chemorefractory ovarian cancer. The treatment led to a significant decrease in CA-125 levels and improvements in tumor-related symptoms.

IMMUNOLOGICAL INVESTIGATIONS (2021)

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Article Biochemistry & Molecular Biology

Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

Can Cui et al.

Summary: The study found that the enrichment of TFH cell transcriptional signature in lung adenocarcinoma patients is correlated with GC B cell signature and prolonged survival. Interactions between tumor-specific TFH and GC B cells are crucial for tumor control and effector CD8 T cell function.

CELL (2021)

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Review Engineering, Biomedical

Nanobiomaterial-based vaccination immunotherapy of cancer

Fangmin Chen et al.

Summary: Cancer vaccines, including antigen peptide/adjuvant-based nanovaccines, nucleic acid-based nanovaccines, and biomimetic nanobiomaterials-based nanovaccines, have shown significant efficacy in inhibiting tumor growth and preventing relapse and metastasis. However, challenges remain in the clinical translation of these vaccines. The use of various nanobiomaterials has great potential to enhance the efficacy of cancer vaccines and reduce off-target effects.

BIOMATERIALS (2021)

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Article Biochemistry & Molecular Biology

Personalized neoantigen vaccine prevents postoperative recurrence in hepatocellular carcinoma patients with vascular invasion

Zhixiong Cai et al.

Summary: Personalized neoantigen vaccine proves to be a safe, feasible, and effective strategy for preventing HCC recurrence, with potential to monitor progression through corresponding neoantigen mutations in ctDNA.

MOLECULAR CANCER (2021)

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Article Chemistry, Multidisciplinary

TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination

Randall Toy et al.

Summary: The study suggests that simultaneous engagement of small molecule adjuvant R848 and RNA adjuvant PUUC can induce robust cellular immune responses in both mice and human cells, enhancing the effectiveness of flu vaccines.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Biomedical

Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation

Qi Su et al.

Summary: The study utilized supramolecular co-assembly to engineer a nanofibrilous hydrogel vaccine platform, which increased antigen uptake, cross-presentation, and activation of dendritic cells significantly. Immunization in mice showed that the co-assembled peptide hydrogel enhanced T-cell immunity and induced a more remarkable cancer immunotherapy efficacy.

BIOACTIVE MATERIALS (2021)

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Article Multidisciplinary Sciences

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Keman Cheng et al.

Summary: The study demonstrates a versatile OMV-based vaccine platform that can elicit a specific anti-tumor immune response by specifically presenting tumor antigens on the OMV surface. By employing a Plug-and-Display system, the engineered OMVs can simultaneously display multiple, distinct tumor antigens to promote a synergistic anti-tumor immune response.

NATURE COMMUNICATIONS (2021)

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Review Nanoscience & Nanotechnology

Multifunctional biomolecule nanostructures for cancer therapy

Jing Wang et al.

Summary: This review discusses the application of biomolecule-based nanostructures in smart cancer nanomedicine. These multifunctional nanostructures, including polysaccharides, nucleic acids, peptides, and proteins, can achieve targeted drug delivery and transport drugs to tumor tissues.

NATURE REVIEWS MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Nanovaccine-Mediated Cell Selective Delivery of Neoantigens Potentiating Adoptive Dendritic Cell Transfer for Personalized Immunization

Ping Xiao et al.

Summary: The combination of neoantigen-loaded nanovaccines and adoptive dendritic cell transfer enhances personalized immunity by facilitating immune cell access to lymph nodes and inhibiting tumor growth.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Mahshid Kharaziha et al.

Summary: The immune reaction plays a critical role in chronic wound healing, with modulation of macrophages' polarization being an appealing approach in regenerative medicine. The use of hydrogels-based constructs has been recently developed to adjust immune cell functions in various stages of wound healing. The properties of hydrogels have significant effects on immunogenic features and the wound healing process.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Personalized combination nano-immunotherapy for robust induction and tumor infiltration of CD8+ T cells

Kyung Soo Park et al.

Summary: The study introduces a novel vaccine platform based on PEI that activates neoantigen-specific CD8+ T cells effectively and achieves tumor infiltration when combined with STING agonist therapy, enhancing anti-tumor efficacy.

BIOMATERIALS (2021)

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Article Cell Biology

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

Long Chen et al.

Summary: Utilizing Escherichia coli cytoplasmic membranes as adjuvants, a vaccine based on hybrid membrane nanoparticles containing tumor cell membranes induced sufficient antitumor reactivity without notable adverse effects, showing efficacy in various tumor mouse models and providing long-term protection against tumor rechallenge.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Multidisciplinary Sciences

A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

Krishna Das et al.

Summary: The combination of a self-adjuvanting protein vaccine and an antigen-expressing oncolytic virus significantly enhances T cell immunogenicity, potentially making non-inflamed tumors proinflammatory and less resistant to checkpoint blockade therapy. Therapeutic cancer vaccination in combination with oncolytic viruses can elicit tumor-specific cytotoxic T cells that offer opportunities to address resistance to checkpoint blockade therapy.

NATURE COMMUNICATIONS (2021)

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Review Oncology

Targeting neoantigens for cancer immunotherapy

Xuan Zhao et al.

Summary: Neoantigens, derived from non-synonymous mutations, have emerged as attractive targets for cancer immunotherapy. Computational prediction and clinical trials have shown promising efficacy and safety, leading to a new era in cancer immunotherapy.

BIOMARKER RESEARCH (2021)

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Review Medicine, Research & Experimental

Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods

Emily K. Makowski et al.

Summary: Developing monoclonal antibodies as therapeutic agents for diverse human disorders has sparked intense interest. Key recent advances in high-throughput methods for identifying antibodies with desirable properties have shown great promise in rational antibody design and prediction of drug-like behaviors, but outstanding challenges remain in fully realizing their potential to minimize development times and improve success rates in the clinic.

MABS (2021)

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Review Nanoscience & Nanotechnology

Bacteria-Inspired Nanomedicine

Maya Holay et al.

Summary: The field of nanomedicine has accelerated significantly in the past decade by drawing inspiration and materials from the natural world. Bacteria-inspired nanomedicines, with their motility, immune modulation, and dynamic interactions, have opened up exciting avenues of research and proven successful in combatting cancer and infectious disease.

ACS APPLIED BIO MATERIALS (2021)

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Review Oncology

Nanomaterial-based delivery vehicles for therapeutic cancer vaccine development

Jie Liang et al.

Summary: Nanomaterial-based vaccines show great potential in enhancing antigen immunogenicity and promoting specific T cell responses for cancer therapy. However, immune responses to tumor-associated antigens may be limited, while vaccines based on neoantigens could be effective for personalized treatments.

CANCER BIOLOGY & MEDICINE (2021)

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Article Chemistry, Applied

Non-small cell lung cancer tumour antigen, MUC-1 peptide-loaded non-aggregated poly (lactide-co-glycolide) nanoparticles augmented cellular uptake in mouse professional antigen-presenting cells: optimisation and characterisation

Kiran Jyoti et al.

JOURNAL OF MICROENCAPSULATION (2020)

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Article Oncology

Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models

Rui Zhang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Sreekanth Pentlavalli et al.

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Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

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ACS CENTRAL SCIENCE (2020)

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Nanoparticles versus Dendritic Cells as Vehicles to Deliver mRNA Encoding Multiple Epitopes for Immunotherapy

Rebuma Firdessa-Fite et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

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A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

Qianqian Ni et al.

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Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines

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Protamine sulphate coated poly (lactide-co-glycolide) nanoparticles of MUC-1 peptide improved cellular uptake and cytokine release in mouse antigen presenting cells

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Ningqiang Gong et al.

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Adaptable antigen matrix platforms for peptide vaccination strategies and T cell-mediated anti-tumor immunity

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Positron Emission Tomography-Guided Photodynamic Therapy with Biodegradable Mesoporous Silica Nanoparticles for Personalized Cancer Immunotherapy

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Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial-Membrane-Coated Nanoparticles

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A Designer Scaffold with Immune Nanoconverters for Reverting Immunosuppression and Enhancing Immune Checkpoint Blockade Therapy

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Ton N. Schumacher et al.

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Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

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Mahesh Yadav et al.

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A vaccine targeting mutant IDH1 induces antitumour immunity

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Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

Pierre G. Coulie et al.

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Ludmil B. Alexandrov et al.

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Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

Hirokazu Matsushita et al.

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