4.6 Review

Magnetic nanoparticles: multifunctional tool for cancer therapy

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Graphene oxide/zinc ferrite nanocomposite loaded with doxorubicin as a potential theranostic mediu in cancer therapy and magnetic resonance imaging

Rizwan Ali et al.

Summary: Hybrid functional biomaterials with biocompatibility and therapeutic and diagnostic characteristics have been developed for target site delivery. In this study, graphene oxide-zinc ferrite hybrid nanocomposites conjugated with doxorubicin were synthesized for cancer therapy and magnetic resonance imaging-based diagnosis. The nanocomposites showed cytotoxicity to cancer cells and induced cell damage and apoptosis by generating reactive oxygen species. The nanocomposites also exhibited potential application in noninvasive MR imaging.

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Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice

Heyu Yang et al.

Summary: This study aimed to evaluate the effects of iron oxide nanoparticles (IONPs) on the male reproductive system of mice. The results showed that IONPs did not affect the major organs, but caused damage to Sertoli cells in the blood-testis barrier (BTB) at a relatively high concentration. This led to a temporary reduction in sperm quantity and quality, which was attributed to increased oxidative stress and apoptotic activity in the epididymis. However, these effects were reversible and returned to normal within 14 days after injection of IONPs.

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Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications

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Summary: Magnetic iron oxide nanoparticles (MNPs) have enormous potential for biomedical applications and can be used as carriers for drugs, nucleic acids, peptides, and other biologically active compounds. The unique properties of MNPs, such as their nanometric size and magnetic properties, along with the incorporation of iron ions into the body's natural circulation, reduce the risk of excessive storage. However, the pharmacokinetics of magnetic nanoparticles play a crucial role in their therapeutic applications, and are influenced by various factors.

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Article Nanoscience & Nanotechnology

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Marzieh Ramezani Farani et al.

Summary: This study introduces the use of magnetic nanoparticles for cancer diagnosis and treatment. The results demonstrate that functionalized nanoparticles have a higher drug-loading capacity and are more likely to be taken up by tumors, making them potential drug delivery systems for cancer therapy. Additionally, when used for diagnosis, FA@HPG@Fe3O4 nanoparticles have the greatest impact on MRI signal enhancement.

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Magnetic Nanoparticles as a Component of Peptide-Based DNA Delivery System for Suicide Gene Therapy of Uterine Leiomyoma

Sofia Shtykalova et al.

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Synergistic Effect of Quercetin Magnetite Nanoparticles and Targeted Radiotherapy in Treatment of Breast Cancer

Mostafa A. Askar et al.

Summary: Quercetin-conjugated magnetite nanoparticles (QMNPs) were successfully prepared using a biological simple nanoprecipitation approach mediated by fungus Aspergillus oryzae. In vitro studies demonstrated the inhibitory effects of QMNPs on MCF-7, HePG-2, and A459 cancer cell lines, while in vivo experiments showed their potential to sensitize breast cancer to radiotherapy. The combination of QMNPs with irradiation effectively blocked cancer cell proliferation and enhanced the therapeutic outcome in a rat model of breast cancer induced by N-methyl-N-nitrosourea, suggesting the potential of QMNPs as a targeted therapy in breast cancer.

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Were magnetic materials useful in cancer therapy?

Roghayyeh Baghban et al.

Summary: Cancer poses a major challenge for biomedical basic research in contemporary times. Magnetite-based nanoparticles have garnered significant attention for cancer therapy due to their magnetic properties, multifunctional design, biodegradability, and biocompatibility. This review provides an overview of the applications of magnetic nanoparticles and recent advancements in utilizing these advanced materials for cancer therapy.

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Design of PEG-modified magnetic nanoporous silica based miltefosine delivery system: Experimental and theoretical approaches

Margarita Popova et al.

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Review Chemistry, Physical

Polymer-Coated Magnetite Nanoparticles for Protein Immobilization

Kinga Mylkie et al.

Summary: Magnetic nanoparticles (MNPs) have great potential in biomedical applications, with synthetic biopolymers used as protective coating for protein immobilization. Recent research has shown advances in the physical and chemical immobilization of enzymes, antibodies, and serum proteins using polymer-coated MNPs.

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Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Chemistry, Physical

Magnetic Nanoparticles Used in Oncology

Veronica Manescu (Paltanea) et al.

Summary: Magnetic nanoparticles (MNPs) are increasingly used in experimental studies on cancer treatments, aiming to treat and cure cancer with minimal side effects through nanotechnology. MNPs can be bonded to various substances and guided under an external magnetic field for different treatment therapies.

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Immunomodulation of Tumor Microenvironment by Arginine-Loaded Iron Oxide Nanoparticles for Gaseous Immunotherapy

Xiaqing Wu et al.

Summary: The study utilized hollow Fe3O4 nanoparticles to reprogram TAMs towards M1 phenotype, activating antitumor immune responses and releasing nitric oxide for synergistic therapy against cancer.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Chemistry, Multidisciplinary

Optimization of Nanoparticles for Smart Drug Delivery: A Review

Lina Jia et al.

Summary: Nanoparticle delivery systems have promising applications in treating various diseases, particularly in cancer treatment, with drug delivery efficacy dependent on nanoparticle properties. Recent studies have focused on optimizing nanoparticle structures, specifically in enhancing biocompatibility, increasing targeting efficiency, and improving drug loading rates.

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Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

Hira Fatima et al.

Summary: The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is an effective technique for targeted cancer therapy. The heating efficiency of magnetic nanoparticles is influenced by factors such as the product values of the applied magnetic field and frequency, as well as protein corona formation.

NANOMATERIALS (2021)

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Magnetic nanoparticles for cancer theranostics: Advances and prospects

Xuexin Li et al.

Summary: Nanoparticles have emerged as a novel approach in cancer diagnosis and treatment, showing great potential in medical applications. However, more research is needed to improve their toxicity and efficacy for clinical use.

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A comparative study on the effects of increase in injection sites on the magnetic nanoparticles hyperthermia

Ali Dahaghin et al.

Summary: The study compared the mechanical response of tumor tissue to single and three site injections, finding that the three-point injection improved the distribution of nanoparticles and heat, increasing tissue damage and decreasing the risk of tissue necrosis.

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Fabrication of Graphene oxide-Fe3O4 nanocomposites for application in bone regeneration and treatment of leukemia

Zhiyun Niu et al.

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Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI

Jordy K. van Zandwijk et al.

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Impact of superparamagnetic iron oxide nanoparticles on in vitro and in vivo radiosensitisation of cancer cells

Emily Russell et al.

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Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy

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Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications

Arbab Ali et al.

Summary: Nanoparticles, particularly magnetic nanoparticles (MNPs), have gained enormous interest for their diverse applications in specialized areas such as medicine, agriculture, and more. Controlled surface engineering is vital for designing multi-functional MNPs. MNPs have demonstrated high efficacy as drug delivery vehicles and biosensors, among other applications.

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Magnetic nanoparticles in biomedical applications: A review

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Summary: Magnetic nanoparticles have significant technological benefits in biomedical applications, particularly in cancer treatment and drug targeting. They possess unique surface chemistry, non-toxicity, biocompatibility, and inducible magnetic moment. Future research should focus on developing advanced and high-performance magnetic nanoparticles.

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Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer

Helena Gavilan et al.

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Advances in Magnetic Nanoparticle-Mediated Cancer Immune-Theranostics

Hung-Wei Cheng et al.

Summary: Magnetic nanoparticles (MNPs) serve as a versatile theranostic tool for targeted delivery of immunotherapeutics and monitoring of cell/tissue responses. By utilizing magnetic properties for navigation and hyperthermia, MNPs enhance the efficacy of immunotherapy. The multimodal approach induces robust immune responses, minimizes safety issues, and allows simultaneous monitoring of immune activities.

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