Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022

Article Infectious Diseases

Detection and characterisation of 16S rRNA methyltransferase-producing Pseudomonas aeruginosa from the UK and Republic of Ireland from 2003-2015

Emma Taylor et al.

Summary: The presence of 16S RMTase genes in Pseudomonas aeruginosa isolates contributes to high-level resistance to aminoglycosides. These genes were found in 8.6% of the isolates, with rmtB4 being the most common. The study also identified a connection between 16S RMTase genes, carbapenemase-producing bacteria, and high-risk clones.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2022)

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Article Public, Environmental & Occupational Health

Epidemiology of carbapenem-resistant and carbapenemase-producing Enterobacterales in the Netherlands 2017-2019

Cornelia C. H. Wielders et al.

Summary: Carbapenem resistance of Enterobacterales in the Netherlands remains low, but the number of CPE isolates has slightly increased. Recent hospitalization abroad is the main risk factor for acquiring CPE.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2022)

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Article Immunology

Rapid Genomic Characterization and Global Surveillance of Klebsiella Using Pathogenwatch

Silvia Argimon et al.

Summary: Pathogenwatch is a web application designed for real-time analysis of Klebsiella genomes, aiding surveillance at local, national, and global levels. The platform allows for contextualization of user genomes with public databases, revealing the distribution of K. pneumoniae clones in different countries through phylogenetic analyses.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

National surveillance pilot study unveils a multicenter, clonal outbreak of VIM-2-producing Pseudomonas aeruginosa ST111 in the Netherlands between 2015 and 2017

Jannette Pirzadian et al.

Summary: In the Netherlands, a national surveillance pilot study in 2016 revealed a nationwide, inter-institutional, clonal outbreak of VIM-2-producing P. aeruginosa lasting at least three years. This highlights the importance of structured, national surveillance programs to monitor the spread of carbapenemase-producing P. aeruginosa and control future outbreaks.

SCIENTIFIC REPORTS (2021)

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Article Infectious Diseases

Increasing frequency of OXA-48-producing Enterobacterales worldwide and activity of ceftazidime/avibactam, meropenem/vaborbactam and comparators against these isolates

Mariana Castanheira et al.

Summary: The study found an increasing trend in the rates of OXA-48-like-producing isolates over 3 years of global surveillance, with Klebsiella pneumoniae being the most common strain. Many isolates carried metallo-beta-lactamases, leading to resistance to most drugs tested. Further research is needed to help physicians understand treatment options for infections caused by these isolates.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

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Article Public, Environmental & Occupational Health

Phenotypic and genotypic characterization of antibiotic resistance in military hospital-associated bacteria from war injuries in the Eastern Ukraine conflict between 2014 and 2020

V Kondratiuk et al.

Summary: This study investigated the antibiotic resistance of pathogens associated with war injuries in the Ukraine conflict, revealing high levels of resistance in Acinetobacter baumannii. Multi-drug-resistant strains carried an abundance of antibiotic resistance genes, with some strains co-producing carbapenemases and RmtASEs.

JOURNAL OF HOSPITAL INFECTION (2021)

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Article Infectious Diseases