Synthetic Strategies for Versatile Thioester Building Blocks

Thioester constitutes a fundamentally unique intermediate, engaged in various biosynthesis processes in living systems as well as a versatile synthon in modern organic synthesis. Transition metal catalysis and radical reaction manifolds have enabled to enrich the repertoire of synthetic methods for thioesters. In this review, we have accommodated the recent reports on modern strategies towards thioester synthesis from a plethora of readily available feedstocks, such as alkenes, alkynes, alcohols, phenols or commodity chemicals/synthetic building blocks like organic aldehydes, halides or organoboron reagents under various catalysis domains. Furthermore, the momentous advancements of employing progenitors of odorous thiols as well as CO-surrogates have contextually been emphasized, alongside the utilization of native free thiols and CO gas.

Automated summary

This review summarizes the recent strategies for thioester synthesis from a variety of readily available feedstocks in modern synthesis. It also highlights the significant advancements in using progenitors of odorous thiols and CO-surrogates, as well as the utilization of native free thiols and CO gas.