期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2022, 期 45, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202201211
关键词
Palladium-catalyzed; C-H olefination; Pyridine igand-promoted; Non-directed; Phenol derivatives
资金
- Natural Science Foundation of China [21772139, 22171197]
- Major Basic Research Project of the natural Science Foundation of Jiangsu Higher Education Institutions [21KJA150002]
- National local joint engineering laboratory to functional adsorption material technology for the environmental protection [SDGC2121]
- PAPD Project
- Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University
An undirected ortho-olefination reaction using tri-isobutyl silicon-protected phenol as the substrate, palladium acetate as the catalyst, and inexpensive pyridine derivatives as ligands was reported. The reaction showed good tolerance towards various phenols, providing moderate to good yields. Importantly, bioactive compounds such as hexyl-methoxyphenol and estradiol were successfully synthesized, highlighting the synthetic importance of this method.
Herein, we report an undirected ortho-olefination reaction using tri-isobutyl silicon-protected phenol as the substrate, palladium acetate as the catalyst, and inexpensive pyridine derivatives as ligands. Various phenols were tolerated well, affording the olefinated product in moderate to good yields. Importantly, bioactive compounds such as hexyl-methoxyphenol and estradiol were tolerated, highlighting the synthetic importance of this method.
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