Protecting-Group-Free Total Synthesis of (-)-Boscartin A in 3 Steps from (-)-Boscartin F via Wharton Reaction

In this report, we described the first total synthesis of (-)-boscartin A, a cembranoid featuring a 5/5/12-fused tricyclic structure. Via the key reactions, including stereoselective epoxidation and Wharton reaction, (-)-Boscartin A was obtained in three steps from (-)-boscartin F, with 46 % overall yield.

Automated summary

In this report, the first total synthesis of (-)-boscartin A, a cembranoid with a 5/5/12-fused tricyclic structure, was described. (-)-Boscartin A was obtained in three steps from (-)-boscartin F, with an overall yield of 46%, utilizing key reactions including stereoselective epoxidation and Wharton reaction.