期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2022, 期 45, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202200947
关键词
Asymmetric catalysis; Enantioselective synthesis; Isoxazolines; Isoxazolinones; Organocatalysis
This review summarizes the methods and importance of enantioselective synthesis of 2-isoxazolines and 2-isoxazolin-5-ones with fully substituted stereocenters, as well as discusses the limitations and future developments in this research field.
Although there is an abundance of methods for the enantioselective synthesis of 2-isoxazolines and 2-isoxazolin-5-ones, relatively few of these approaches have been reported when these heterocycles bear fully substituted stereocenters. In this review, we will detail the methods that have been used to successfully accomplish these challenging asymmetric transformations and give insights into their importance, such as allowing access to unique three-dimensional chemical space. The limitations of the currently known reactions will be discussed, as well as highlighting the future developments needed to advance the research field.
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