期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 26, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202201065
关键词
Arylglyoxal; Annulation; Imidazole; Imidazo[2; 1-a]isoquinolin-6(5H)-ones; Ruthenium
Novel 5-hydroxyimidazo[2,1-a]isoquinolin-6(5H)-ones were synthesized by Ru(II)-catalyzed reaction of 2-arylimidazoles with arylglyoxals. The method provided moderate to good yields and could be scaled up for synthesis. The reaction involved imidazole-directed Ru(II)-catalyzed ortho-dicarbonylation followed by nucleophilic cyclization. Photophysical properties of the newly synthesized compounds were investigated.
Synthesis of novel 5-hydroxyimidazo[2,1-a]isoquinolin-6(5H)-ones have been achieved by Ru(II)-catalyzed reaction of 2-arylimidazoles with arylglyoxals. The method provided moderate to good yields of 5-hydroxyimidazo[2,1-a]isoquinolin-6(5H)-ones and is amenable to gram-scale synthesis. The reaction involves imidazole-directed Ru(II)-catalyzed ortho-dicarbonylation followed by nucleophilic cyclization of the NH-group with the carbonyl group. Photophysical properties of the newly synthesized 5-hydroxyimidazo-[2,1-a]isoquinolin-6(5H)-ones were investigated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据