☆ 4.7 Article

Design, synthesis and biological evaluation of a new series of arylidene indanones as small molecules for targeted therapy of non-small cell lung carcinoma and prostate cancer

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Endocrinology & Metabolism

An update on the current status and future prospects of erectile dysfunction following radical prostatectomy

Heba Asker et al.

Summary: This article provides a comprehensive overview of the current treatments for post-RP erectile dysfunction (ED), evaluates the underlying pathological mechanisms, and emphasizes promising therapeutic strategies based on evidence from basic research. However, clinical trial results for erectogenic drugs in this setting are conflicting, and the effectiveness of some treatment methods remains uncertain. It is necessary to transform potential treatment strategies into clinically applicable safe and effective techniques to improve erectile function after RP.

PROSTATE (2022)

添加到收藏夹

Review Oncology

From Therapy Resistance to Targeted Therapies in Prostate Cancer

Filipa Moreira-Silva et al.

Summary: Prostate cancer is the second most common malignancy among men. Early-stage disease is curable, but advanced stage PCa is mostly incurable and resistant to standard therapeutic options. Individualized analysis and selective targeted therapy may improve treatment outcomes.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Therapeutic Strategies to Target the Androgen Receptor

Weiguo Xiang et al.

Summary: The androgen receptor (AR) is crucial in maintaining muscle and bone, supporting male sexual functions, and progressing prostate cancer. Various AR-targeted therapies have been developed, including AR agonists for bone loss and muscle atrophy, and AR antagonists for prostate cancer treatment.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Apoptosis-Inducing Potential of Selected Bromophenolic Flame Retardants 2,4,6-Tribromophenol and Pentabromophenol in Human Peripheral Blood Mononuclear Cells

Anna Baranska et al.

Summary: This study found that 2,4,6-TBP and PBP can induce apoptosis in human PBMCs and have effects on multiple parameters of the cells. The mitochondrial pathway plays a major role in the apoptosis process of PBMCs exposed to these substances.

MOLECULES (2022)

添加到收藏夹

Article Oncology

Modeling prostate cancer: What does it take to build an ideal tumor model?

Chun-Wai Mai et al.

Summary: Prostate cancer is characterized by multifocality and a high propensity to metastasize to bone. Evaluating the capability of preclinical models in replicating key genomic alterations and tumor features is crucial. The use of emerging organoid models in prostate cancer research shows clear advantages over traditional preclinical tumor models.

CANCER LETTERS (2022)

添加到收藏夹

Review Pathology

Morphologic spectrum of treatment-related changes in prostate tissue and prostate cancer: an updated review

Katrina Collins et al.

Summary: There are a wide range of treatment options available for patients with prostate cancer, including surgery, radiation therapy, focal therapy, and chemotherapy. The histopathologic changes induced by different treatments need to be evaluated by pathologists. In cases where clinical history is lacking but morphologic features suggest prior treatment, consultation with clinical colleagues is recommended.

HUMAN PATHOLOGY (2022)

添加到收藏夹

Review Oncology

A pharmacological exploration of targeted drug therapy in non-small cell lung cancer

Ajay P. Jayan et al.

Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer accounting for 85%. Traditional chemotherapy has been replaced by targeted therapy, which has minimal side effects and focuses on tumor cells. In the past two decades, many small molecules have been developed to target specific proteins or genes, but resistance mechanisms and activation of bypass signaling pathways remain challenges.

MEDICAL ONCOLOGY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and biological evaluation of chalcone-polyamine conjugates as novel vectorized agents in colorectal and prostate cancer chemotherapy

Benjamin Rioux et al.

Summary: This study aimed to enhance bioavailability and selectivity of chalcone core towards cancer cells by synthesizing chalcone-polyamine conjugates, which showed significant anti-proliferative effects on colorectal and prostate cancer cell lines. The most active conjugate was found to inhibit cell proliferation by blocking the cell cycle at the G1 and G2 phase, and inducing apoptosis through several pro-apoptotic markers. The chalcone-N1-spermidine conjugate could be considered as a promising agent for colon and prostatic cancer adjuvant therapy.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Anticancer Activity of Natural and Synthetic Chalcones

Teodora Constantinescu et al.

Summary: Cancer is a disease caused by various mechanisms, and targeted therapy is the most effective approach. Flavonoids, particularly chalcones, show promising anticancer activity due to their ability to act on multiple targets. Modifying chalcone structures can lead to compounds with superior cytotoxic properties, with derivatives containing different heterocycles like azoles showing potential as new anticancer agents.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Medicine, General & Internal

Prostate cancer

Richard J. Rebello et al.

Summary: Prostate cancer is a prevalent disease among men, with key genetic alterations including gene fusions, oncogene amplification, and mutations in androgen receptors. Treatment options range from active surveillance to surgery and radiotherapy for localized disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Caspase-3: A primary target for natural and synthetic compounds for cancer therapy

Poonam Yadav et al.

Summary: Caspase-3 plays a crucial role in cancer treatment, with many compounds reported to have potential anticancer effects through caspase-3-mediated apoptosis; plant isolates have also demonstrated cytotoxicity through caspase-3-mediated apoptosis. Procaspase-activating compound-1 is the first FDA-approved orphan drug, and its synthetic derivative has shown anticancer activity.

CHEMICAL BIOLOGY & DRUG DESIGN (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Recent advances in chalcone-based anticancer heterocycles: A structural and molecular target perspective

Vishal Kumar et al.

Summary: Chalcones are a class of compounds with diverse biological activities that are beneficial to human health. Their anticancer activities are achieved through the inhibition of various molecular targets, and understanding the mechanisms may lead to the development of more effective anticancer drugs.

CURRENT MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer

Yohei Saito et al.

Summary: The study found that compound 5 exhibited potent antitumor activity by inducing cell death through cell cycle disruption, while also interacting with multiple cancer cell growth-related proteins.

MOLECULES (2021)

添加到收藏夹

Review Medicine, General & Internal

Prostate cancer

Shahneen Sandhu et al.

Summary: Management of prostate cancer is rapidly evolving with advances in understanding the genomic landscape, improved imaging methods, and personalised therapeutics targeting DNA repair pathways. The therapeutic framework for metastatic disease has shifted, with oligometastatic disease being evaluated for metastatic-directed therapies, and novel androgen pathway inhibitors showing significant survival benefits as first-line therapy for metastatic disease. Emerging research into molecular characterisation and novel therapeutics, such as targeted radioisotopes and immunotherapy, hold promise for improving patient outcomes.

LANCET (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products

Iksen et al.

Summary: Lung cancer is a common and highly lethal cancer, posing a major clinical challenge. The PI3K/AKT/mTOR pathway has been linked to lung cancer, making it a significant therapeutic target. Interest in targeting these pathways with medications has grown, showing promise in various types of studies.

MOLECULES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Cathepsin D-Managing the Delicate Balance

Olja Mijanovic et al.

Summary: Lysosomal proteases, specifically human cathepsin D, play a crucial role in maintaining cell homeostasis by managing protein turnover. Dysregulation of cathepsin D can contribute to various disorders, such as neurodegenerative diseases and cancer progression. Targeting cathepsin D could provide significant diagnostic benefits and innovative therapeutic approaches.

PHARMACEUTICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chalcone Derivatives: Role in Anticancer Therapy

Yang Ouyang et al.

Summary: Chalcones, as precursors for flavonoids and isoflavonoids, have shown broad biological activities and potential as novel anticancer agents. They demonstrate multiple mechanisms against cancers and are expected to improve therapeutic efficacy in combination with other therapies. The full description of toxicity is necessary for their safe clinical use for cancer treatment.

BIOMOLECULES (2021)

添加到收藏夹

Review Cell Biology

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

Tulasi Yadati et al.

CELLS (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Novel PI3K/Akt/mTOR pathway inhibitors plus radiotherapy: Strategy for non -small cell lung cancer with mutant RAS gene

Kai Chen et al.

LIFE SCIENCES (2020)

添加到收藏夹

Review Chemistry, Medicinal

Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure-activity relationship

Feng Gao et al.

MEDICINAL RESEARCH REVIEWS (2020)

添加到收藏夹

Review Oncology

Mechanisms and Future of Non-Small Cell Lung Cancer Metastasis

Tianhao Zhu et al.

FRONTIERS IN ONCOLOGY (2020)

添加到收藏夹

Article Chemistry, Medicinal

Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?

Lorenzo Cianni et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of novel synthetic chalcone derivatives as anti-tumor agents targeting Cat L and Cat K

Yali Wang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Surgery

Caspase-3, a key apoptotic protein, as a prognostic marker in gastric cancer after curative surgery

Kuo-Hung Huang et al.

INTERNATIONAL JOURNAL OF SURGERY (2018)

添加到收藏夹

Article Oncology

Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents

Ahmet Ozdemir et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Review Chemistry, Medicinal

Recent developments in biological activities of indanones

Siddappa A. Patil et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Review Cell Biology

Taking out the garbage: cathepsin D and calcineurin in neurodegeneration

Andreas Aufschnaiter et al.

NEURAL REGENERATION RESEARCH (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Arylidene indanone scaffold: medicinal chemistry and structure-activity relationship view

Jose C. J. M. D. S. Menezes

RSC ADVANCES (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting calcium signaling in cancer therapy

Chaochu Cui et al.

ACTA PHARMACEUTICA SINICA B (2017)

添加到收藏夹

Review Oncology

Cathepsin D as a Promising Target for the Discovery of Novel Anticancer Agents

Vijaya Dubey et al.

CURRENT CANCER DRUG TARGETS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Calcium regulates cell death in cancer: Roles of the mitochondria and mitochondria-associated membranes (MAMs)

Alberto Danese et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Chalcone: A Privileged Structure in Medicinal Chemistry

Chunlin Zhuang et al.

CHEMICAL REVIEWS (2017)

添加到收藏夹

Review Oncology

A Review on Mechanisms of Anti Tumor Activity of Chalcones

Rahul Sharma et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Activation of apoptosis signalling pathways by reactive oxygen species

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and anti-proliferative activity of fluoro-substituted chalcones

Serdar Burmaoglu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer

Aastha Singh et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2016)

添加到收藏夹

Review Oncology

Therapeutic management of bone metastasis in prostate cancer: an update

Fable Zustovich et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2016)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo

Jun Yan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis and Evaluation of New Benzodioxole-Based Thiosemicarbazone Derivatives as Potential Antitumor Agents

Mehlika Dilek Altintop et al.

MOLECULES (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting DNA Damage Response in the Radio(Chemo)therapy of Non-Small Cell Lung Cancer

Ling Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Calcium and mitochondria in the regulation of cell death

Sten Orrenius et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cathepsin S: therapeutic, diagnostic, and prognostic potential

Richard D. A. Wilkinson et al.

BIOLOGICAL CHEMISTRY (2015)

添加到收藏夹

Article Oncology

Targeted Therapies for Prostate Cancer

Roberto Petrioli et al.

CANCER INVESTIGATION (2015)

添加到收藏夹

Review Oncology

Molecular histology of lung cancer: From targets to treatments

Steven L. Wood et al.

CANCER TREATMENT REVIEWS (2015)

添加到收藏夹

Article Pharmacology & Pharmacy

Non-Small Cell Lung Carcinoma: An Overview on Targeted Therapy

Ana Vanessa Nascimento et al.

CURRENT DRUG TARGETS (2015)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents

Ahmet Ozdemir et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

添加到收藏夹

Review Chemistry, Medicinal

Anti-cancer chalcones: Structural and molecular target perspectives

Debarshi Mar Mahapatra et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

添加到收藏夹

Article Pharmacology & Pharmacy

Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule

Aastha Singh et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

添加到收藏夹

Review Pharmacology & Pharmacy

Cathepsin L targeting in cancer treatment

Dhivya R. Sudhan et al.

PHARMACOLOGY & THERAPEUTICS (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer

Md Zahidul Islam Pranjol et al.

BIOMOLECULES (2015)

添加到收藏夹

Review Oncology

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response

Oakley C. Olson et al.

NATURE REVIEWS CANCER (2015)

添加到收藏夹

Article Oncology

Molecular Targeted Approaches to Cancer Therapy and Prevention Using Chalcones

Danielle D. Jandial et al.

CURRENT CANCER DRUG TARGETS (2014)

添加到收藏夹

Article Chemistry, Medicinal

Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins

Chun Wai Mai et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

添加到收藏夹

Article Oncology

Advances in Chalcones with Anticancer Activities

Chandrabose Karthikeyan et al.

Recent Patents on Anti-Cancer Drug Discovery (2014)

添加到收藏夹

Article Chemistry, Medicinal

Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents

Seok-Ho Kim et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity

Ahmet Ozdemir et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium

Freddie L. Pruitt et al.

PROSTATE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization

A. P. Prakasham et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2012)

添加到收藏夹

Review Pharmacology & Pharmacy

Overcoming Drug Resistance and Treating Advanced Prostate Cancer

Julius Semenas et al.

CURRENT DRUG TARGETS (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exploring Pharmacological Significance of Chalcone Scaffold: A Review

N. K. Sahu et al.

CURRENT MEDICINAL CHEMISTRY (2012)

添加到收藏夹

Review Gastroenterology & Hepatology

Cathepsins and pancreatic cancer: The 2012 update

Sara Sulpizio et al.

PANCREATOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro

Ishita Deb Majumdar et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

添加到收藏夹

Review Chemistry, Multidisciplinary

Lung Cancer and Its Early Detection Using Biomarker-Based Biosensors

Sunil K. Arya et al.

CHEMICAL REVIEWS (2011)

添加到收藏夹

Article Biochemical Research Methods

A Flow-Cytometric Method for Continuous Measurement of Intracellular Ca2+ Concentration

Alice Vines et al.

CYTOMETRY PART A (2010)

添加到收藏夹

Review Medicine, Research & Experimental

Cathepsin L, target in cancer treatment?

Jacqueline M. Lankelma et al.

LIFE SCIENCES (2010)

添加到收藏夹

Review Oncology

Targeted therapy in non-small-cell lung cancer-is it becoming a reality?

Filip Janku et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy

Xin Zheng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)

添加到收藏夹

Review Oncology

Management of complications of prostate cancer treatment

M. Dror Michaelson et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2008)

添加到收藏夹

Review Biochemistry & Molecular Biology

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

P. Pinton et al.

ONCOGENE (2008)

添加到收藏夹

Article Oncology

Quafity of life for men with prostate cancer

Anne Katz

CANCER NURSING (2007)

添加到收藏夹

Review Pharmacology & Pharmacy

Emerging roles of cysteine cathepsins in disease and their potential as drug targets

Olga Vasiljeva et al.

CURRENT PHARMACEUTICAL DESIGN (2007)

添加到收藏夹

Review Oncology

Cathepsin D:: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis

Emmanuelle Liaudet-Coopman et al.

CANCER LETTERS (2006)

添加到收藏夹

Article Oncology

Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells

LM Leoni et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.