A close look into the biological and synthetic aspects of fused pyrazole derivatives

The fusion of pyrazole scaffold with other skeletons creates a class of attractive molecules, demonstrating significant biological and chemical potentiality in the development of medicinal chemistry. Over the past few decades, numerous biologically active molecules featuring fused pyrazole moieties have been excavated and synthesized, some of which represented by sildenafil have been marketed as drugs, and the biological importance together with chemical synthesis strategies of fused pyrazole compounds, including structural modification based on lead compounds, have been steadily progressing. In this review, we focused our attention on the biological importance of fused pyrazoles and highlighted recent progress in the synthesis of this framework over the past 10 years. What' s more, the limitations, challenges, and future prospects were proposed, wishing to provide references for the development of pyrazole fused frameworks in the field of medicinal chemistry. Contents.

Automated summary

The fusion of pyrazole scaffold with other skeletons creates attractive molecules with significant biological and chemical potential in medicinal chemistry. Over the past few decades, numerous biologically active molecules featuring fused pyrazole moieties have been discovered and synthesized, some of which have become marketed drugs. This review focuses on the biological importance of fused pyrazoles and highlights recent progress in their synthesis over the past 10 years, while also discussing limitations, challenges, and future prospects.