Structure activity relationship (SAR) and anticancer activity of pyrrolidine derivatives: Recent developments and future prospects (A review)

Pyrrolidine molecules are a significant class of synthetic and natural plant metabolites, which show the diversity of pharmacological activities. An extensive variety of synthetic pyrrolidine compounds with numerous deriva-tization like spirooxindole, thiazole, metal complexes, coumarin, etc have revealed significant anticancer ac-tivity. Pyrrolidine molecules are found not only as potential anticancer candidates but also retain the lowest side effects. Depending upon the diverse substitution patterns of the derivatives, these molecules have demonstrated an incredible ability to regulate the various targets to give excellent anti-proliferative activities. Taking these into consideration, efforts have been taken by the scientific fraternity to design and develop a potent anticancer scaffold with negligible side effects. In the present review, we cover the latest advancements in the synthesis of pyrrolidine molecules which have promising anticancer activity toward numerous cancer cell lines. Additionally, it also highlights the effectiveness of derivatives via elucidation of Structural-Activity-Relationship (SAR) which is discussed in detail.

Automated summary

Pyrrolidine molecules are important for their diverse pharmacological activities and have significant anticancer activity. Synthetic derivatives of pyrrolidine, such as spirooxindole, thiazole, metal complexes, and coumarin, have been developed to have potent anticancer activity with minimal side effects. These molecules have demonstrated an incredible ability to regulate various targets and have promising anticancer activity against multiple cancer cell lines. The review also highlights the effectiveness of derivatives through the elucidation of Structural-Activity-Relationship (SAR).